Results 101 to 110 of about 36,910 (309)

Determination of Penicillins Residues in Livestock and Marine Products by LC/MS/MS [PDF]

, 2011
Multi-residue analysis method for penicillins was developed and validated in bovine muscle, chicken, milk, and flatfish. Detection was based on liquid chromatography tandem mass spectrometry (LC/MS/MS). The developed method was validated for specificity,
Hyunjin Joo, Ji Young Song, Joung Boon Hwang, Mi Ok Kim, Dae Hyun Cho, Soo Jung Hu, Shin Jung Kang   +6 more
core   +1 more source

Toxicity of the Penicillins [PDF]

Postgraduate Medical Journal, 1964
THE absence of direct toxicity is one of the most remarkable properties of the penicillin molecule; that is to say, the penicillin molecule as we know it and as we should use it. If you try hard enough, you can make it toxic by altering it or abusing it, as I shall try to show later.
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

SIDE-CHAIN SPECIFICITY IN THE ENZYMATIC-SYNTHESIS OF PENICILLINS [PDF]

, 1990
5-Carboxynaphth-1-oyl-, 4-carboxybenxoyl-,trans-5-carboxy-3-pentenoyl- and cis-5-carboxy-3-pentenoyl-L-cysteinyl-D-valine were shown to be converted by isopenicillin N synthetase to their corresponding penicillins in yields of 90%, 12%, 40% and 5 ...
SCHOFIELD, C, Bradley D. Smith, Jack E. Baldwin, Christopher J. Schofield, BALDWIN, J, SMITH, B   +5 more
core   +1 more source

Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations.

Frontiers in Cellular and Infection Microbiology, 2014
Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when ...
Jennifer eKintner, Dawn eLajoie, Jennifer eHall, Judy eWhittimore, Robert V Schoborg   +4 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Penicillin allergy assessment pathway to improve antibiotic use: the ALABAMA intervention development, RCT, process and cost-effectiveness evaluation

Programme Grants for Applied Research
Background People with penicillin allergy labels receive more antibiotics, different antibiotics and have worse health outcomes when compared to people without a penicillin allergy label.
Jonathan AT Sandoe, Jenny Boards, Christopher C Butler, Philip Howard, Rubén Mújica-Mota, Catherine E Porter, Sinisa Savic, Sarah Tonkin-Crine, Marta Wanat, Robert M West, Ly-Mee Yu, Susan H Pavitt   +11 more
doaj   +1 more source

Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 [PDF]

Brazilian Journal of Pharmaceutical Sciences
Healthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance.
Giuliana Amanda de Oliveira, Adriano Max Moreira Reis   +1 more
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evaluation of Beta-lactam antibacterials and penicillins consumption [PDF]

, 2016
Background: The beta-lactam family of antibiotics includes the majority of the most heavily used antibacterials in clinical medicine. They are important, both historically and currently, because of their effectiveness and generally low toxicity.
Bernaz, Emilian P.
core