Results 141 to 150 of about 4,583,036 (340)

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

open access: yesChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova   +15 more
wiley   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely   +14 more
wiley   +1 more source

Varied Presentations of Carcinoma Penis in India: A Case Series

open access: yesJournal of Clinical and Diagnostic Research
Penile cancer is an uncommon but significant malignancy affecting men, with a disproportionate burden in developing countries. India has one of the highest incidences of penile cancer in the world, with rates as high as 3.32 per 100,000 men.
Abhirudra Mulay   +3 more
doaj   +1 more source

Do Prices Matter for Healthcare Accessibility? Evidence From a Means‐Tested Complementary Health Insurance in France

open access: yesHealth Economics, EarlyView.
ABSTRACT In France, the Couverture Maladie Universelle Complémentaire (CMU‐C) scheme is a means‐tested, state‐financed, complementary health insurance program that fully covers healthcare. Using administrative claims data and a staggered difference‐in‐differences approach, we estimate the impact of enrollment in the program on healthcare utilization ...
Benoît Carré   +2 more
wiley   +1 more source

Prostate cancer with synchronous metastatic penile lesion: A case report

open access: yesUrology Case Reports
Prostate cancer with penile metastasis is exceedingly rare. We report a synchronous metastatic hormone-sensitive prostate cancer presenting initially as a penile lesion in a 70-year-old male.
Muhammad Fajar   +5 more
doaj   +1 more source

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