Results 211 to 220 of about 51,168 (257)
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Pentose phosphate pathway mutants of yeast
Molecular and General Genetics MGG, 1982A glucose-negative mutant of Saccharomyces cerevisiae lacking 6-phosphogluconate dehydrogenase, the second enzyme of the pentose phosphate pathway, has been obtained by inositol starvation. Suppression of this mutant for growth on glucose takes place by the loss of glucose 6-phosphate dehydrogenase.
Z, Lobo, P K, Maitra
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The Pentose Phosphate Pathway in Parasitic Trypanosomatids
Trends in Parasitology, 2016Parasitic trypanosomatids cause important diseases. Dissecting the biochemistry of these organisms offers a means of discovering targets against which inhibitors may be designed and developed as drugs. The pentose phosphate pathway is a key route of glucose metabolism in most organisms, providing NADPH for use as a cellular reductant and various ...
Julie, Kovářová, Michael P, Barrett
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Control of the pentose-phosphate pathway in yeast
Biochimica et Biophysica Acta (BBA) - General Subjects, 1969Abstract 1. 1. The aim of this work was to investigate whether variation in the amounts of the enzyme of the glycolytic and pentose-phosphate pathways controlled carbohydrate oxidation in Candida utilis . 2. 2. The activities of glucose-6-phosphate dehydrogenase ( d -glucose-6-phosphate: NADP + oxidoreductase, EC 1.1.1.49) and transketolase
C B, Osmond, T, Ap Rees
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1998
The pentose phosphate pathway (also known as the phosphogluconate pathway or the hexose monophosphate shunt) provides a route by which glucose can be oxidized to carbon dioxide. As in the case of glycolysis, the substrate for the pathway is glucose-6-phosphate. An outline of the pathway is shown in Figure 15.1.
J. M. Chesworth +2 more
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The pentose phosphate pathway (also known as the phosphogluconate pathway or the hexose monophosphate shunt) provides a route by which glucose can be oxidized to carbon dioxide. As in the case of glycolysis, the substrate for the pathway is glucose-6-phosphate. An outline of the pathway is shown in Figure 15.1.
J. M. Chesworth +2 more
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The Pentose Phosphate and Entner-Doudoroff Pathways
2004The pentose phosphate pathway of carbohydrate metabolism is an oxidative pathway, in contrast to the Embden–Meyerhof pathway of glycolysis. In this pathway, glucose 6-phosphate, derived from glucose by phosphorylation can be totally degraded to carbon dioxide, accompanied by the reduction of NADP+ to NADPH.
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The pentose phosphate pathway and parasitic protozoa
Parasitology Today, 1997The pentose phosphate pathway plays a crucial role in the host-parasite relationship. It maintains a pool of NADPH, which serves to protect against oxidant stress and which generates carbohydrate intermediates used in nucleotide and other biosynthetic pathways.
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Disorders of the Pentose Phosphate Pathway
2006Three inborn errors in the pentose phosphate pathway are known. In glucose-6-phosphate dehydrogenase deficiency, there is a defect in the first, irreversible step of the pathway. As a consequence NADPH production is decreased, making erythrocytes vulnerable to oxidative stress.
Nanda M. Verhoeven, Cornelis Jakobs
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The pentose phosphate pathway in cystic fibrosis erythrocytes
Biochemical and Biophysical Research Communications, 1970Abstract Glucose-6-phosphate dehydrogenase (G6PD), NADP and NADPH were compared in red blood cells (rbc's) of cystic fibrosis (CF) patients and sex and age matched controls. G6PD activity was higher in CF rbc's (P = .03). NADPH/NADP ratios were decreased in CF rbc's (P= .003). These findings are viewed in terms of an increased cellular need for NADPH
B L, Shapiro, S M, Lee, W J, Warwick
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The Pentose Phosphate Pathway in Brain during Development
Biology of the Neonate, 2009Sprague-Dawley rats were delivered in our laboratory and decapitated at ages varying between 1 and 60 days. The concentrations of 6-phosphogluconate in extracts of the brain were determined in these litters and in adult rats. The highest content of 6-phosphogluconate was seen in brains of 3-day-old rats when it was at that age more than six times the ...
A M, Hakim, G, Moss, D, Scuderi
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A Newer Pathway Of Carbohydrate Metabolism; The Pentose Phosphate Pathway
Diabetes, 1956In the past thirty years a vast body of information has been compiled relating to carbohydrate metabolism. Nevertheless, it is becoming increasingly evident that the elucidation of the metabolic disturbance in diabetes mellitus requires an even more complete knowledge than is presently available of the complex chemical routes followed by glucose in its
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