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Biological actions of pentraxins
Vascular Pharmacology, 2015The innate immunity is the first defense reaction against microorganisms or altered self-components upon tissue injury. Such exogenous or modified endogenous molecules present conserved molecular structures that are recognized by the immune system via pattern-recognition receptors or molecules.
Gemma, Vilahur, Lina, Badimon
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Levels of Serum Pentraxin 3, IL-6, Fetuin a and Insulin in Patients With Rheumatoid Arthritis
Cytokine, 2016 Conclusion: Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA. (C) 2016 Elsevier Ltd.
Ayhan Kamanlı, Sinem Sag, Kemal Nas
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Structure and function of the pentraxins
Current Opinion in Immunology, 1995Over the past two years, the three-dimensional structure of the serum amyloid P component was defined by X-ray diffraction, the first such visualization of a pentraxin. Binding sites for calcium, ligands and complement were identified. New fusion proteins with amino acid sequence homology to the pentraxins were described, and new insights were gained ...
H, Gewurz, X H, Zhang, T F, Lint
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Pentraxins and Atherosclerosis: The Role of PTX3
Current Pharmaceutical Design, 2011Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins.
Garlanda, Cecilia +6 more
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Pentraxins in Humoral Innate Immunity
2011Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognise pathogens associated molecular ...
A. Inforzato +4 more
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Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3
Journal of Clinical Immunology, 2007Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein and serum amyloid P-component are classic short pentraxins produced in the liver, whereas the prototype of ...
A. Mantovani +3 more
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2007
Innate immunity is the first line of defense against pathogens. It plays a key role in the activation and orientation of adaptive immunity. Recognition and elimination of pathogens and of dying cells is mediated by pattern recognition receptors (PPRs) that have both cellular and humoral components.
Uday Kishore, Kenneth B.M. Reid
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Innate immunity is the first line of defense against pathogens. It plays a key role in the activation and orientation of adaptive immunity. Recognition and elimination of pathogens and of dying cells is mediated by pattern recognition receptors (PPRs) that have both cellular and humoral components.
Uday Kishore, Kenneth B.M. Reid
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Pentraxin-3 and endothelial dysfunction
2019Pentraxin 3 (PTX3) is involved in vascular inflammation and endothelial dysfunction through various mechanisms. Until now, most studies confirmed an important link between PTX3 and endothelial dysfunction and identified several pathogenetic pathways. PTX3 modulates inflammatory cells, thus stimulating vascular inflammation. Within endothelial cells, it
Alexandru, Zlibut +2 more
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Pentraxins: CRP and PTX3 and Cardiovascular Disease
Inflammation & Allergy - Drug Targets, 2011The pentraxins, C-reactive protein (CRP), serum amyloid P (SAP) and pentraxin3 (PTX3) are useful biomarkers for cardiovascular disease (CVD), particularly ischemic heart disease and heart failure, and are deeply involved in the pathogenesis of CVD linked to inflammation and innate immunity.
Yuichiro, Maekawa +2 more
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The long pentraxin PTX3 in vascular pathology
Vascular Pharmacology, 2006Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins.
A. Mantovani +6 more
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