Results 1 to 10 of about 10,062 (208)

Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. [PDF]

PLoS ONE, 2011
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes.
Maciej Lech, Christoph Römmele, Onkar P Kulkarni, Heni Eka Susanti, Adriana Migliorini, Cecilia Garlanda, Alberto Mantovani, Hans-Joachim Anders   +7 more
doaj   +2 more sources

Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.

PLoS ONE, 2012
PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting
Elisa Barbati, Claudia Specchia, Massimo Villella, Marco Luciano Rossi, Simona Barlera, Barbara Bottazzi, Luisa Crociati, Carmela d'Arienzo, Raffaele Fanelli, Cecilia Garlanda, Francesca Gori, Ruggiero Mango, Alberto Mantovani, Giuseppe Merla, Enrico B Nicolis, Silvia Pietri, Patrizia Presbitero, Yukio Sudo, Alessandro Villella, Maria Grazia Franzosi   +19 more
doaj   +4 more sources

Autoantibodies against pentraxin-3 in systemic lupus erythematosus: mapping of reactivity to linear epitopes and associations with disease variables

Autoimmunity
The pentraxin-3 (PTX3) protein can activate and modulate complement and immune cells. IgG anti-PTX3 antibodies are suggested to protect against lupus nephritis (LN).
Jesper Karlsson, Helena Enocsson, Hanna Duàn, Suhana Ahmad, Daniel Appelgren, Alf Kastbom, Lina Wirestam, Christopher Sjöwall, Jonas Wetterö   +8 more
doaj   +1 more source

Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.

PLoS ONE, 2012
BackgroundPentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 is produced by immune and structural cells.
Jingbo Zhang, Lianyu Shan, Latifa Koussih, Naresh Singh Redhu, Andrew J Halayko, Jamila Chakir, Abdelilah S Gounni   +6 more
doaj   +1 more source

Expression and Clinical Significance of Serum PTX3 in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the expression and clinical significance of serum PTX3 in HCC patients. Methods We selected 78 HCC patients as the liver cancer group, and 78 cases of healthy subjects as the healthy control group.
PANG Kangqing, MA Hongde, YANG Rulei, PANG Guohong   +3 more
doaj   +1 more source

PTX3 as a diagnostic and prognostic biomarker in lung adenocarcinoma: a comprehensive analysis

Discover Oncology
Background Lung cancer remains a leading global cause of mortality, with lung adenocarcinoma (LUAD) as the predominant histological subtype. Current serum biomarkers like carcinoembryonic antigen (CEA) lack specificity, necessitating novel diagnostic ...
Shaobo Zhou, Na Li, Dina Haishaer, Hongmei Zhao   +3 more
doaj   +1 more source

Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome.

PLoS ONE, 2013
The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic inflammation,
Simone Bastrup-Birk, Mikkel-Ole Skjoedt, Lea Munthe-Fog, Jens J Strom, Ying Jie Ma, Peter Garred   +5 more
doaj   +1 more source

Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis

Cellular Physiology and Biochemistry, 2016
Background/Aims: Tubulointerstitial fibrosis can lead to end-stage renal disease. Pentraxin 3 (PTX3) is an acute phase protein produced by resident and innate immunity cells.
Tung-Wei Hung, Jen-Pi Tsai, Shin-Huey Lin, Chien-Hsing Lee, Yi-Hsien Hsieh, Horng-Rong Chang   +5 more
doaj   +1 more source

Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection

Mediators of Inflammation, 2014
Purpose. The long pentraxin 3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to proinflammatory stimuli. We reviewed the usefulness of systemic levels of PTX3 in critically ill patients with
Siguan Liu, Xin Qu, Feng Liu, Chunting Wang   +3 more
doaj   +1 more source

PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway

Open Life Sciences, 2023
Sun Ye, Liu Lihua, Yang Ruihua
doaj   +1 more source