Results 21 to 30 of about 10,062 (208)

Single-cell sequencing reveals PTX3 involvement in ovarian cancer metastasis

Journal of Ovarian Research
Background Pentraxin 3 (PTX3) has been associated with the development and progression of various malignant tumors. However, its roles and the mechanisms underlying its involvement in ovarian cancer (OC) peritoneal metastasis remain unclear.
Shuangyan Liu, Tianhao Wu, Xueying Song, Linru Quan, Xinyi Wang, Qing Liu, Xin Zhou   +6 more
doaj   +2 more sources

Pentraxin 3 ameliorates glucocorticoid-induced osteonecrosis of the femoral head via TLR4/NF-κB/FGF21 signaling axis [PDF]

Communications Biology
Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a debilitating bone disorder characterized by impaired osteogenesis and apoptosis-driven bone collapse.
Jinxu Li, Zhonghua Zhou, Yan Kong, Yang Li, Zhe Wang, Yongkang Yang, Jingyi Wang, Tianyi Liu, Xinyu Wang, Dan Luo, Fan Zhang, Cheng Qiu, Jingwei Liu   +12 more
doaj   +2 more sources

Promoting role of pentraxin-3 in esophageal squamous cell carcinoma

Molecular Therapy: Oncolytics, 2022
Pentraxin 3 (PTX3) is an inflammatory molecule that is closely related to the proliferation, invasion, and metastasis of cancer. In order to explore the role of PTX3 in the occurrence and development of esophageal carcinoma (ESCA), we modified the PTX3 ...
Zhirui Fan, Yuanyuan Zheng, Xiaoli Li, Xiaoming Deng, Yan Ba, Kun Feng, Jin Su, Hui Wang, Zhenhe Suo, Lifeng Li   +9 more
doaj   +1 more source

Prediction of Respiratory Failure and Mortality in COVID-19 Patients Using Long Pentraxin PTX3

Journal of Innate Immunity, 2022
The course of COVID-19 is unpredictable, ranging from asymptomatic to respiratory failure and death. Prognostic biomarkers are urgently needed. We hypothesized that long pentraxin PTX3 could be a valuable plasma biomarker due to its essential role in ...
Cecilie Bo Hansen, Håkon Sandholdt, Maria Elizabeth Engel Møller, Laura Pérez-Alós, Lise Pedersen, Simone Bastrup Israelsen, Peter Garred, Thomas Benfield   +7 more
doaj   +1 more source

Sugar-Rich Food Intake Is Negatively Associated with Plasma Pentraxin 3 Levels

Journal of Obesity & Metabolic Syndrome, 2023
Background : Levels of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, increase after weight loss in obese men and aerobic exercise in non-obese adults. However, the effect of nutritional characteristics on PTX3 levels remains unclear.
Asako Zempo-Miyaki, Hiroshi Kumagai, Koichiro Tanahashi, Hirofumi Zempo, Takeshi Otsuki, Seiji Maeda   +5 more
doaj   +1 more source

In Silico design and in vitro validation for siRNA targeting PTX3 gene in glioma cell line

Fiyz̤, 2022
Background: Identification of underlying mechanisms of gliomas pathogenesis is of particular importance. The overexpression of PTX3 gene is profoundly implicated in glioma development. The RNA interference (RNAi)-based knockdown of target gene by means
Reza Ahmadi-Beni, Shirin Shahbazi, Alireza Khoshnevisan, Javad Behroozi   +3 more
doaj  

Role of PTX3 in allergic airway inflammation [PDF]

, 2016
Thesis Abstract: Pentraxin 3 (PTX3) is a pattern recognition receptor that plays an important role in providing immunity against various pulmonary inflammatory conditions.
Balhara, Jyoti
core   +1 more source

Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3.

, 2006
Long-pentraxin 3 (PTX3) is a soluble pattern recognition receptor with non-redundant functions in inflammation and innate immunity. PTX3 comprises a pentraxin-like C-terminal domain involved in complement activation via C1q interaction and an N-terminal ...
BOTTAZZI B, CAMOZZI M, VINCENTI S, PRESTA M., BUGATTI A, BRACCI, LUISA, RUSNATI M, BASTONE A, MANTOVANI A, INFORZATO, A, MASTROIANNI D   +10 more
core   +3 more sources

Endogenous Long Pentraxin 3 Exerts a Protective Role in a Murine Model of Pulmonary Fibrosis

Frontiers in Immunology, 2021
Pulmonary fibrosis is a progressive scarring disease of the lungs, characterized by inflammation, fibroblast activation, and deposition of extracellular matrix.
Federica Maccarinelli, Mattia Bugatti, Mattia Bugatti, Ander Churruca Schuind, Sara Ganzerla, William Vermi, William Vermi, Marco Presta, Roberto Ronca   +8 more
doaj   +1 more source

PTX3 orchestrates tissue repair

Oncotarget, 2015
Innate immunity is the first line of resistance against pathogens, but it has also an important role in maintaining tissue homeostasis by regulating inflammatory and repair responses after tissue injury [1]. Innate immunity consists of a cellular and humoral arm [1, 2]. It has been clearly established that cell-associated pattern-recognition molecules (
Andrea, Doni, Cecilia, Garlanda, Alberto, Mantovani   +2 more
openaire   +2 more sources