Results 31 to 40 of about 10,062 (208)

Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration.

PLoS ONE, 2015
Age-related macular degeneration (AMD) has been associated with both systemic and ocular alterations of the immune system. In particular dysfunction of complement factor H (CFH), a soluble regulator of the alternative pathway of the complement system ...
Helene Bæk Juel, Carsten Faber, Lea Munthe-Fog, Simone Bastrup-Birk, Alexander Lynge Reese-Petersen, Mads Krüger Falk, Amardeep Singh, Torben Lykke Sørensen, Peter Garred, Mogens Holst Nissen   +9 more
doaj   +1 more source

PTX3 acts as an extrinsic oncosuppressor

Oncotarget, 2015
Inflammation is an essential component of the tumor microenvironment that sustains tumor development and growth [1]. The role in cancer-related inflammation of innate immunity cells recruited in the tumor has been clarified in preclinical models.
Eduardo, Bonavita, Alberto, Mantovani, Cecilia, Garlanda   +2 more
openaire   +2 more sources

PTX3 shapes profibrotic immune cells and epithelial/fibroblast repair and regeneration in a murine model of pulmonary fibrosis [PDF]

, 2023
The long pentraxin 3 (PTX3) is protective in different pathologies but was not analyzed in-depth in Idiopathic Pulmonary Fibrosis (IPF). Here, we have explored the influence of PTX3 in the bleomycin (BLM)-induced murine model of IPF by looking at immune ...
Turati M., Maccarinelli F., Lorusso L., Tamma R., Ronca R., De Giorgis M., Ribatti D., d'Amati A., Annese T., d’Amati, Antonio, Turati, Marta, Annese, Tiziana, Maccarinelli, Federica, De Giorgis, Michelina, d'Amati, Antonio, Tamma, Roberto, Ronca, Roberto, Lorusso, Loredana, Ribatti, Domenico   +18 more
core   +2 more sources

HDL, PTX3, and Vascular Protection [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
The superfamily of pentraxins consists of evolutionary conserved acute phase proteins characterized by the presence of a multimeric structural motif, the pentraxin domain (reviewed in1). C-reactive protein and serum amyloid P represent the short pentraxin arm of this family and are mainly produced by the liver.
Ziad Mallat, Alain Tedgui
openaire   +1 more source

Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma

International Journal of Nanomedicine, 2022
Marie-Thérèse Aloy,1,* Jacqueline Sidi Boumedine,2,* Agathe Deville,2,3 David Kryza,2 Arnaud Gauthier,1,4 Delphine Brichart-Vernos,1,5 Grégoire Ollier,1 Veronica La Padula,5 François Lux,5 Olivier Tillement,5 Claire Rodriguez-Lafrasse,1,4,&ast ...
Aloy MT, Sidi Boumedine J, Deville A, Kryza D, Gauthier A, Brichart-Vernos D, Ollier G, La Padula V, Lux F, Tillement O, Rodriguez-Lafrasse C, Janier M   +11 more
doaj  

The Role of PTX3 in Mineralization Processes and Aging-Related Bone Diseases

Frontiers in Immunology, 2021
The Long Pentraxin 3 (PTX3) is a multifunctional glycoprotein released by peripheral blood leukocytes and myeloid dendritic cells in response to primary pro-inflammatory stimuli, that acts as a non-redundant component of the humoral arm of innate ...
Umberto Tarantino, Umberto Tarantino, Chiara Greggi, Chiara Greggi, Chiara Greggi, Ida Cariati, Ida Cariati, Ida Cariati, Virginia Veronica Visconti, Virginia Veronica Visconti, Virginia Veronica Visconti, Monica Gasparini, Monica Gasparini, Marco Cateni, Marco Cateni, Elena Gasbarra, Elena Gasbarra, Annalisa Botta, Antonietta Salustri, Manuel Scimeca   +19 more
doaj   +1 more source

STUDY OF PLASMA PENTRAXIN 3 LEVELS AS A NOVEL MARKER VERSUS LIVER STIFFNESS FOR NONALCOHOLIC STEATOHEPATITIS IN EGYPTIAN PATIENTS [PDF]

Ain Shams Medical Journal, 2022
Background: In Nonalcoholic fatty liver disease (NAFLD), histopathological differentiating from simple steatosis to nonalcoholic steatohepatitis (NASH) can only be confirmed by liver biopsy.
Ramy Ghait, Shady Ghait, Hanan Hassan, Eslam Mohammed, Hanan Badawy, Shaimaa GadAllah   +5 more
doaj   +1 more source

PTX3: A Potential Biomarker in Thyroid Associated Ophthalmopathy [PDF]

BioMed Research International, 2018
Background. Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Methods.
Pei Mou, Ziyu Chen, Lihong Jiang, Jinwei Cheng, Ruili Wei   +4 more
openaire   +2 more sources

Plasma pentraxin 3 levels do not predict coronary events but reflect metabolic disorders in patients with coronary artery disease in the CARE trial.

PLoS ONE, 2014
Chronic inflammation closely associates with obesity, metabolic syndrome, diabetes mellitus, and atherosclerosis. Evidence indicates that the immunomodulator pentraxin 3 (PTX3) may serve as a biomarker of these cardiometabolic disorders, but whether PTX3
Tetsuro Miyazaki, Stephanie Chiuve, Frank M Sacks, Paul M Ridker, Peter Libby, Masanori Aikawa   +5 more
doaj   +1 more source

THE PROTECTIVE ROLE OF PTX3 IN MOUSE SKIN CARCINOGENESIS [PDF]

, 2015
The implication of the innate immune system on inflammatory carcinogenesis is a central topic in tumor biology. The humoral pattern recognition molecule PTX3 plays a fundamental role in the modulation of inflammation by regulating Complement cascade and ...
S. Gentile
core   +1 more source