Results 51 to 60 of about 10,062 (208)
An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode [PDF]
, 2015 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the humoral arm of innate immunity. In four different models of tissue damage in mice, PTX3 deficiency was associated with increased fibrin deposition and persistence,
A. Ponzetta (23449396) +21 more
core +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Myasthenia gravis (MG) is an autoantibodies-mediated autoimmune disease with the complications of neuromuscular junction transmission. In this study, we aimed to investigate the molecular regulatory roles of pentaxin 3 (PTX3) in patients and ...
Yao Li +3 more
doaj +1 more source
Glucocorticoids regulate pentraxin-3 expression in human airway smooth muscle cells.
PLoS ONE, 2019 Pentraxin-3 (PTX3) is a multifunctional protein involved in both innate and adaptive immunity. Glucocorticoid (GC) is the first-line therapy to mitigate airway inflammation in asthma.
Jingbo Zhang +5 more
doaj +1 more source
Advanced Science, EarlyView.AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang +19 more
wiley +1 more source
Molecular Medicine, 2016 The signals causing resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute.
Michela Vezzoli +13 more
doaj +1 more source
Journal of Men's Health, 2022 Background: Obesity, an independent cardiovascular disease risk factor, is the leading cause of death in the world. It has been previously shown that arterial stiffness,which is an index of cardiovascular disease, is significantly higher in Japanese ...
Asako Zempo-Miyaki +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede +11 more
wiley +1 more source
Associação entre os níveis séricos de pentraxina 3 e a mortalidade de pacientes vítimas de traumatismo crânio-encefálico grave [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2010Introdução: O trauma cranioencefálico (TCE), é a umas das maiores causas de morbidade e ...
Gullo, Jackson da Silva
core
Apoptosis and PTX3 in lichen planus
Advances in Dermatology and AllergologyLichen planus (LP) is considered a T cell-mediated autoimmune disease although its aetiology remains unknown. Cytotoxic T cells play a central role in the pathogenesis of LP and these cells are known to significantly induce apoptosis in basal keratinocytes.To correlate pentraxin 3 (PTX3) with apoptosis in basal cell keratinocytes in LP and to determine
Yavuz, Ibrahim H. +5 more
openaire +2 more sources