Results 61 to 70 of about 10,062 (208)

The Long Pentraxin PTX3 in Bone Homeostasis and Pathology [PDF]

Frontiers in Immunology, 2019
The innate immune system is equipped with a number of germ-line encoded soluble pattern recognition molecules (PRMs) that collectively mediate the humoral host response to infection and damage in cooperation with cells and tissues of the immune and non-immune compartments.
Raffaella Parente, Cristina Sobacchi, Cristina Sobacchi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Danka Grčevic, Danka Grčevic, Antonio Inforzato, Antonio Inforzato   +10 more
openaire   +4 more sources

Elevated circulating levels and tissue expression of pentraxin 3 in uremia: a reflection of endothelial dysfunction.

PLoS ONE, 2013
Elevated systemic pentraxin 3 (PTX3) levels appear to be a powerful marker of inflammatory status and a superior outcome predictor in patients with chronic kidney disease (CKD).
Anna Witasp, Mikael Rydén, Juan Jesús Carrero, Abdul Rashid Qureshi, Louise Nordfors, Erik Näslund, Folke Hammarqvist, Samsul Arefin, Karolina Kublickiene, Peter Stenvinkel   +9 more
doaj   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Characterization of the long pentraxin PTX3 as a TNFα-induced secreted protein of adipose cells

Journal of Lipid Research, 2003
Exposure of preadipocytes to long-chain fatty acids induces the expression of several markers of adipocyte differentiation. In an attempt to identify novel genes and proteins that are regulated by fatty acids in preadipocytes, we performed a substractive
Anissa Abderrahim-Ferkoune, Olivier Bezy, Chiara Chiellini, Margherita Maffei, Paul Grimaldi, Frédéric Bonino, Naïma Moustaid-Moussa, Fabio Pasqualini, Alberto Mantovani, Gérard Ailhaud, Ez-Zoubir Amri   +10 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Efficacy of PTX3 in a Rat Model of Invasive Aspergillosis [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT Pentraxin 3 (PTX3) is an acute-phase glycoprotein with a nonredundant function in the host resistance to Aspergillus fumigatus . PTX3 activity was evaluated against pulmonary aspergillosis in rats immunosuppressed with cortisone acetate.
Pietro, Lo Giudice, Silvia, Campo, Antonio, Verdoliva, Vincenzo, Rivieccio, Franco, Borsini, Rita, De Santis, Giovanni, Salvatori   +6 more
openaire   +2 more sources

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Production of the Long Pentraxin PTX3 in Advanced Atherosclerotic Plaques

, 2002
Elevated plasma levels of the pentraxin protein family member C-reactive protein (CRP) are associated with increased risk of cardiovascular disease in both healthy and high-risk subjects. The long pentraxin family member, pentraxin 3 (PTX3), was recently
Barbara Bottazzi, Göran K. Hansson, Alberto Mantovani, Sabine Zimmer, Cecilia Garlanda, Michael S. Rolph, Hansson, GK, Bottazzi, B, Zimmer, S, Garlanda, C, Rolph, MS, Mantovani, A   +11 more
core   +1 more source

The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects

Mycobiology, 2020
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells.
Yuening Kang, Yuetian Yu, Liangjing Lu
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source