Results 51 to 60 of about 114,651,738 (212)

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole–Pyrazole Hybrid Scaffolds as Multi‐Target Anti‐Ulcer Agents

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The hybrid pharmacophore approach involves the combination of benzimidazole‐pyrazole moieties to form multi‐functional anti‐ulcer compounds. Molecular modeling and biological evaluations show significant proton pump inhibition, anti‐inflammatory action, antioxidant property, and remarkable prevention of gastric ulcers.
Hafiz Aamir Ali Kharl   +8 more
wiley   +1 more source

Twin Studies on Urinary Pepsinogen A Phenotypes and Serum Pepsinogen A Levels

open access: yesActa geneticae medicae et gemellologiae: twin research, 1987
AbstractUrinary pepsinogen A (PGA or PG I) phenotypes and serum PGA levels were studied in MZ and DZ twins and their parents. In 45 out of 48 MZ twin pairs PGA patterns were completely identical, while 3 MZ twin pairs showed minor differences in the relative intensity of the Pg5 isozymogen.
Pronk, J.C.   +7 more
openaire   +4 more sources

P64

open access: yesEJC Supplements, 2015
Adenoma and adenocarcinoma of the stomach are related to precancerous states and considered as successive stages of disregeneratory process proceeding against a background of chronic inflammation relying on cytokine-producing function of immune cells ...
A. Sosnina   +5 more
doaj   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

open access: yesMovement Disorders Clinical Practice, Volume 13, Issue 9, Page 2081-2092, September 2026.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz   +2 more
wiley   +1 more source

Covalent structure of chicken pepsinogen [PDF]

open access: yesEuropean Journal of Biochemistry, 1983
Chicken pepsinogen is a glycoprotein consisting of a single polypeptide chain and containing the following 367 amino acid residues: Asp23, Asn16, Thr26, Ser41, Glu14, Gln11, Pro18, Gly31, Ala17, Cys7, Val25, Met9, Ile23, Leu28, Tyr22, Phe20, His8, Lys17, Arg7, Trp4. The Mr‐value of the protein is 42074.
M, Baudys, V, Kostka
openaire   +3 more sources

Gastric Mucosal Molecular Alterations and Multimodal Field‐Based Risk Models for Gastric Cancer Development

open access: yesCancer Science, Volume 117, Issue 9, Page 2323-2334, September 2026.
DNA methylation in non‐neoplastic background gastric mucosa reflects cumulative inflammatory and exposure‐related field changes before cancer develops. Combining methylation with clinical, endoscopic, histological, and emerging multimodal information may refine calibrated gastric cancer risk prediction and support risk‐adapted personalized endoscopic ...
Genki Usui, Atsushi Kaneda
wiley   +1 more source

Control mechanisms of mammalian pepsinogen secretion [PDF]

open access: yes, 1989
The objective of this thesis was to delineate aspects of the control mechanisms of mammalian pepsinogen secretion. In order to accomplish this goal, a comprehensive study was undertaken which would establish an historical perspective of the subject ...
Modlin, Irvin M
core   +1 more source

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome. [PDF]

open access: yesPLoS ONE, 2016
BACKGROUND:Helicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by ...
Atsushi Takeoka   +7 more
doaj   +1 more source

Beyond Helicobacter pylori: Prevalence, Coinfection, and Clinicopathologic Patterns of Non‐Helicobacter pylori Helicobacter (NHPH) in Human Gastric Biopsies

open access: yesHelicobacter, Volume 31, Issue 5, September/October 2026.
ABSTRACT Background Non‐Helicobacter pylori Helicobacter (NHPH) species are increasingly recognized as human gastric colonizers, yet their prevalence, species distribution, and clinical significance remain incompletely defined, particularly in patient cohorts in the Middle East.
Daniel Vizenblit   +5 more
wiley   +1 more source

Factors Predicting Effectiveness of Eradication Therapy for Helicobacter pylori-Associated Dyspepsia Symptoms

open access: yesLife
Functional dyspepsia is distinguishable from Helicobacter pylori-associated dyspepsia. However, distinguishing H. pylori-associated dyspepsia from functional dyspepsia before H. pylori eradication is difficult.
Kohei Yasuda   +14 more
doaj   +1 more source

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