Results 171 to 180 of about 1,324 (208)

Pepsinogens in gastric carcinomas

Human Pathology, 1986
Polyclonal rabbit antisera raised against the two major groups of human pepsinogens (PG I and PG II) were used in an immunohistochemical study of human gastric carcinomas. Thirty-two carcinomas, classified histologically according to the Lauren classification as diffuse or intestinal, were studied; and the staining patterns of the tumor and adjacent ...
R M, Busby-Earle, A R, Williams, J, Piris   +2 more
openaire   +2 more sources

Pepsinogen

Journal of Clinical Gastroenterology, 1987
Pepsin is a potent proteolytic enzyme stored and secreted by chief cells in an inactive precursor form, pepsinogen. Its secretion is modulated by both cAMP and calcium-dependent mechanisms. Abnormalities in levels of pepsinogen and its various isozymogens have been linked clinically, epidemiologically, and experimentally to peptic ulcer disease and ...
M D, Basson, I M, Modlin
openaire   +2 more sources

THE CONTROL OF PEPSINOGEN SECRETION*

Annals of the New York Academy of Sciences, 1967
SummaryThe peptic cell makes and secretes a protein (pepsinogen) and the cellular mechanisms governing the rate of synthesis and its relation to secretion are described and schematically illustrated.The peptic cell as a system secreting protein exists side by side with the parietal cell transporting H+, Cl, water and electrolytes.
openaire   +2 more sources

Pepsinogen A/pepsinogen C or pepsinogen A multiplied by gastrin in the diagnosis of gastric cancer?

The Italian journal of gastroenterology, 1991
Being pepsinogen A (PGA) levels generally reduced and pepsinogen C (PGC) increased in gastric cancer patients, PGA/PGC ratio has been proposed as a useful marker of the tumour. We tested PGA, PGC and Gastrin (G) levels in patients with gastric cancer (39) and, as a control, in patients with epithelial dysplasia (21), chronic atrophic gastritis (57 ...
FARINATI, FABIO, DIMARIO F, PLEBANI, MARIO, CIELO R, FANTON MC, VALIANTE F, MASIERO M, DEBONI M, DELLALIBERA G, BURLINA A, NACCARATO R.   +10 more
openaire   +2 more sources

The Ratio of Pepsinogen A to Pepsinogen C: A Sensitive Test for Atrophic Gastritis

Scandinavian Journal of Gastroenterology, 1989
To diagnose fundic atrophic (type A) gastritis as part of the clinical investigation of various diseases or for epidemiologic purposes, a simple and reliable diagnostic test would be of great value. We studied circulating levels of pepsinogen A (PGA) and pepsinogen C (PGC) in 179 patients with fundic atrophic gastritis, 29 unselected patients with ...
K, Borch, C K, Axelsson, H, Halgreen, M D, Damkjaer Nielsen, T, Ledin, P B, Szesci   +5 more
openaire   +2 more sources

Structural studies on pepsinogen and pepsin tryptic digests of pepsinogen and pepsin

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1967
Reduced-carboxymethylated pepsinogen and pepsin were digested with trypsin. The peptides were separated on Sephadex G-25. Four fractions were obtained, designated as A, B, C, and D. Nearly identical proportions of amino acids were found in Fractions A and D of the two digests indicating that A and D of the pepsinogen digest originate from the pepsin ...
A B, Oestreicher, G E, Perlmann
openaire   +2 more sources

Cell-specific hypomethylation of the pepsinogen gene in pepsinogen-producing cells

Biochemical and Biophysical Research Communications, 1988
The pepsinogen gene is hypomethylated in the stomach, in which it is expressed. For demonstration that this hypomethylation of the pepsinogen gene in the stomach reflects pepsinogen-producing cells, we analyzed fractions of dispersed mucosal cells with various contents of pepsinogen-producing cells prepared from guinea pig stomach by centrifugal ...
Masao Ichinose, Kazumasa Miki, Masae Tatematsu, Takakazu Mizuno, Mamoru Mutai, Chie Furihata, Yoshikazu Ichihara, Takeshi Ishihara, Masao Tanji, Hiroshi Oka, Yoshikazu Hinohara, Takayuki Takahashi, Takashi Kageyama, Kenji Takahashi   +13 more
openaire   +2 more sources

Intramolecular Activation of Pepsinogen

1977
Two pathways for pepsinogen activation have been demonstrated. Intramolecular activation, which is kinetically first-order, predominates over the autocatalytic pathway if the pH is below 3 and the protein concentration is less than 1 mg/ml during activation.
J A, Hartsuck, J, Marciniszyn, J S, Huang, J, Tang   +3 more
openaire   +2 more sources

ANTIBODIES TO PEPSINOGEN AND PEPSINOGEN MODIFICATIONS*

Annals of the New York Academy of Sciences, 1963
Ruth Arnon, Gertrude E. Perlmann
openaire   +1 more source

Serum pepsinogen I levels in relation to pepsinogen phenotypes.

Progress in clinical and biological research, 1985
Serum PG I levels were measured by an enzyme linked immuno sorbent assay (ELISA) in 567 blood donors and 171 patients from a routine gastroscopy program to study the relationship between PG I phenotypes and serum levels. In normal subjects no association was found between PG I phenotypes and serum levels.
G, Pals, I, Biemond, J, Défize, B D, Westerveld, J C, Pronk, S G, Meuwissen, A W, Eriksson   +6 more
openaire   +1 more source