Results 1 to 10 of about 3,746,064 (390)

Efficient Synthesis of Isoquinoline Derivatives through Sequential Cyclization–Deoxygenation Reaction of 2-Alkynylbenzaldoximes

SynOpen, 2022
We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi, Ali Nikbakht, Kamran Amiri, Alireza Abbasi Kejani, Hossein Zahedian Tejeneki, Saeed Balalaie   +5 more
doaj   +1 more source

Adjuvant DNA vaccine pNMM promotes enhanced specific immunity and anti-tumor effects

Human Vaccines & Immunotherapeutics, 2023
DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added to enhance immunogenicity.
Yu Wang, Weiwei Song, Qiang Xu, Yachao Liu, Hezhong Liu, Runzi Guo, Chuang-Jiun Chiou, Kun Gao, Baofeng Jin, Changfeng Chen, Zhongming Li, Jinqi Yan, Jiyun Yu   +12 more
doaj   +1 more source

Total wash elimination for solid phase peptide synthesis

Nature Communications, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins, Sandeep K. Singh, Travis A. White, Drew J. Cesta, Colin L. Simpson, Levi J. Tubb, Christopher L. Houser   +6 more
doaj   +1 more source

Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy

Pharmaceutics, 2023
Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.
Beáta Biri-Kovács, Zoltán Bánóczi, Anitha Tummalapally, Ildikó Szabó   +3 more
doaj   +1 more source

Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity

Communications Biology, 2021
Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy.
Fayun Zhang, Zifeng Zheng, Apurba Kumar Barman, Zihao Wang, Luyao Wang, Wenfeng Zeng, Luoyang Wang, Yan Qin, Asmita Pandey, Chunling Zhang, Wei Liang   +10 more
doaj   +1 more source

Activation of the adipocyte CREB/CRTC pathway in obesity

Communications Biology, 2021
Yoon et al show that a high fat diet in mice activates the CREB/CRTC pathway in adipocytes by decreasing the expression of Salt Inducible Kinase 2 (SIK2), a Ser/Thr kinase that otherwise phosphorylates and sequesters CREB coactivators in the cytoplasm ...
Young-Sil Yoon, Weiyi Liu, Sam Van de Velde, Shigenobu Matsumura, Ezra Wiater, Ling Huang, Marc Montminy   +6 more
doaj   +1 more source

Quantifying systemic molecular networks affected during high altitude de-acclimatization

Scientific Reports, 2023
High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better ...
Subhojit Paul, Shikha Jain, Anamika Gangwar, Swaraj Mohanty, Nilofar Khan, Yasmin Ahmad   +5 more
doaj   +1 more source

Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents. [PDF]

, 2016
OBJECTIVE: The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells.
Chen, Chang-Po, Kumar, Pardeep, Mehta, Neil, Paudyal, Bishnuhari, Thakur, Mathew L., Tripathi, Sushil Kumar, Wickstrom, Eric   +6 more
core   +2 more sources

Alamethicin self-assembling in lipid membranes: concentration dependence from pulsed EPR of spin labels [PDF]

, 2018
The antimicrobial action of the peptide antibiotic alamethicin (Alm) is commonly related to peptide self-assembling resulting in the formation of voltage-dependent channels in bacterial membranes, which induces ion permeation.
De Zotti, Marta, Dzuba, Sergei A, Formaggio, Fernando, Syryamina, Victoria N, Toniolo, Claudio   +4 more
core   +1 more source

Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

Journal of Hematology & Oncology, 2018
Background Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy.
Erhao Zhang, Jieyi Gu, Jianpeng Xue, Chenyu Lin, Chen Liu, Mengwei Li, Jingchao Hao, Sarra Setrerrahmane, Xiaowei Chi, Weiyan Qi, Jialiang Hu, Hanmei Xu   +11 more
doaj   +1 more source