Results 1 to 10 of about 3,087,616 (415)

Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell penetrating peptides [PDF]

Biophysical Journal, Volume 97, Issue 7, 7 October 2009, Pages 1917-1925, 2009
Recent molecular dynamics simulations (Herce and Garcia, PNAS, 104: 20805 (2007)) have suggested that the arginine-rich HIV Tat peptides might be able to translocate by destabilizing and inducing transient pores in phospholipid bilayers. In this pathway for peptide translocation, arginine residues play a fundamental role not only in the binding of the ...
Enrique, N., Garcia, A. E., Herce, H. D., Kane, R. S., Litt, J., Martin, P., Milesi, V., Rebolledo, A.   +7 more
arxiv   +6 more sources

Efficient Synthesis of Isoquinoline Derivatives through Sequential Cyclization–Deoxygenation Reaction of 2-Alkynylbenzaldoximes

SynOpen, 2022
We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi, Ali Nikbakht, Kamran Amiri, Alireza Abbasi Kejani, Hossein Zahedian Tejeneki, Saeed Balalaie   +5 more
doaj   +1 more source

Adjuvant DNA vaccine pNMM promotes enhanced specific immunity and anti-tumor effects

Human Vaccines & Immunotherapeutics, 2023
DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added to enhance immunogenicity.
Yu Wang, Weiwei Song, Qiang Xu, Yachao Liu, Hezhong Liu, Runzi Guo, Chuang-Jiun Chiou, Kun Gao, Baofeng Jin, Changfeng Chen, Zhongming Li, Jinqi Yan, Jiyun Yu   +12 more
doaj   +1 more source

Total wash elimination for solid phase peptide synthesis

Nature Communications, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins, Sandeep K. Singh, Travis A. White, Drew J. Cesta, Colin L. Simpson, Levi J. Tubb, Christopher L. Houser   +6 more
doaj   +1 more source

Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy

Pharmaceutics, 2023
Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.
Beáta Biri-Kovács, Zoltán Bánóczi, Anitha Tummalapally, Ildikó Szabó   +3 more
doaj   +1 more source

Identifying sequential residue patterns in bitter and umami peptides [PDF]

ACS Food Sci. Technol. 2022, 2, 11, 1773--1780, 2022
The primary structures of peptides, originating from food proteins, affect their taste. Connecting primary structure to taste, however, is difficult because the size of the peptide sequence space increases exponentially with increasing peptide length, while experimentally-labeled data on peptides' tastes remain scarce.
arxiv   +1 more source

Optimal combination treatment regimens of vaccine and radiotherapy augment tumor-bearing host immunity

Communications Biology, 2021
Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy.
Fayun Zhang, Zifeng Zheng, Apurba Kumar Barman, Zihao Wang, Luyao Wang, Wenfeng Zeng, Luoyang Wang, Yan Qin, Asmita Pandey, Chunling Zhang, Wei Liang   +10 more
doaj   +1 more source

Activation of the adipocyte CREB/CRTC pathway in obesity

Communications Biology, 2021
Yoon et al show that a high fat diet in mice activates the CREB/CRTC pathway in adipocytes by decreasing the expression of Salt Inducible Kinase 2 (SIK2), a Ser/Thr kinase that otherwise phosphorylates and sequesters CREB coactivators in the cytoplasm ...
Young-Sil Yoon, Weiyi Liu, Sam Van de Velde, Shigenobu Matsumura, Ezra Wiater, Ling Huang, Marc Montminy   +6 more
doaj   +1 more source

Quantifying systemic molecular networks affected during high altitude de-acclimatization

Scientific Reports, 2023
High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better ...
Subhojit Paul, Shikha Jain, Anamika Gangwar, Swaraj Mohanty, Nilofar Khan, Yasmin Ahmad   +5 more
doaj   +1 more source

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]

, 2019
OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter, Bahnson, Henry T., Blum, Janice, Considine, Robert V., Davis, Asa K., DiMeglio, Linda A., Evans-Molina, Carmella, Greenbaum, Carla J., Haataja, Leena, Marcovina, Santica, Mastracci, Teresa L., Mirmira, Raghavendra G., Morris, Margaret A., Nadler, Jerry, Nyalwidhe, Julius, Qian, Wei-Jun, Schmidt, C. Max, Sims, Emily K., Speake, Cate, Swensen, Adam C., T1D Exchange Residual C-peptide Study Group, Yi, Lian, Yip-Schneider, Michele   +22 more
core   +1 more source