Results 1 to 10 of about 2,267,521 (292)
SynOpen, 2022 We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi +5 more
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Adjuvant DNA vaccine pNMM promotes enhanced specific immunity and anti-tumor effects
Human Vaccines & Immunotherapeutics, 2023 DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added to enhance immunogenicity.
Yu Wang +12 more
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Total wash elimination for solid phase peptide synthesis
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy
Pharmaceutics, 2023 Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.
Beáta Biri-Kovács +3 more
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Communications Biology, 2021 Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy.
Fayun Zhang +10 more
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Activation of the adipocyte CREB/CRTC pathway in obesity
Communications Biology, 2021 Yoon et al show that a high fat diet in mice activates the CREB/CRTC pathway in adipocytes by decreasing the expression of Salt Inducible Kinase 2 (SIK2), a Ser/Thr kinase that otherwise phosphorylates and sequesters CREB coactivators in the cytoplasm ...
Young-Sil Yoon +6 more
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Quantifying systemic molecular networks affected during high altitude de-acclimatization
Scientific Reports, 2023 High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better ...
Subhojit Paul +5 more
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Advanced Science, 2022 The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with
Hongxia Duan +10 more
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Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes [PDF]
, 2019 OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory
Arvan, Peter +22 more
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Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume. [PDF]
, 2017 Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a strategy to develop peptide-based therapeutic nanoparticles by screening a peptide library differing by single-site amino acid ...
Landry, Markita P +4 more
core +1 more source