Results 1 to 10 of about 2,341,910 (347)
SynOpen, 2022 We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of ...
Mojtaba Ayoubi +5 more
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Adjuvant DNA vaccine pNMM promotes enhanced specific immunity and anti-tumor effects
Human Vaccines & Immunotherapeutics, 2023 DNA vaccines containing only antigenic components have limited efficacy and may fail to induce effective immune responses. Consequently, adjuvant molecules are often added to enhance immunogenicity.
Yu Wang +12 more
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Total wash elimination for solid phase peptide synthesis
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy
Pharmaceutics, 2023 Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.
Beáta Biri-Kovács +3 more
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Marine Invertebrate Peptides: Antimicrobial Peptides [PDF]
Frontiers in Microbiology, 2021 Antimicrobial peptides are an important component of many organisms’ innate immune system, with a good inhibitory or killing effect against the invading pathogens. As a type of biological polypeptide with natural immune activities, antimicrobial peptides have a broad spectrum of antibacterial, antiviral, and antitumor activities.
Ran Wu +9 more
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Communications Biology, 2021 Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy.
Fayun Zhang +10 more
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C-peptide is a bioactive peptide [PDF]
Diabetologia, 2007 -ATPase.Nerveconductionvelocity.RedbloodcelldeformabilityAbbreviationsBB/Wor BioBreeding/WorcestereNOS endothelial nitric oxide synthaseICAM-1 intracellular adhesion molecule 1MAPK mitogen-activated protein kinaseNCV nerve conduction velocityDuring the past decade, reports from several laboratorieshave focused on the physiological effects of C-peptide ...
John Wahren, Hans Jörnvall, K. Ekberg
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Activation of the adipocyte CREB/CRTC pathway in obesity
Communications Biology, 2021 Yoon et al show that a high fat diet in mice activates the CREB/CRTC pathway in adipocytes by decreasing the expression of Salt Inducible Kinase 2 (SIK2), a Ser/Thr kinase that otherwise phosphorylates and sequesters CREB coactivators in the cytoplasm ...
Young-Sil Yoon +6 more
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, 2021 Peptides produced by hydrolysis of milk proteins during technological processes and storage greatly influence the functional and biological properties of dairy products. This chapter deals with the main analytical techniques for milk peptide analysis.
Recio, Isidra +3 more
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Advanced Science, 2022 The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with
Hongxia Duan +10 more
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