Results 21 to 30 of about 2,268,571 (366)

Label-free method for anti-glucopeptide antibody detection in Multiple Sclerosis

MethodsX, 2015
Surface plasmon resonance technique is particularly interesting in immunology because it has the potential to visualize label-free antigen-antibody interactions in real-time, thus enabling antibody detection and monitoring.
Feliciana Real-Fernández, Giada Rossi, Francesco Lolli, Anna Maria Papini, Paolo Rovero   +4 more
doaj   +1 more source

The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1 [PDF]

, 2017
BACKGROUND/OBJECTIVE: The extent of influence of BMI and age on C-peptide at the diagnosis of type 1 diabetes (T1D) is unknown. We thus studied the impact of body mass index Z-scores (BMIZ) and age on C-peptide measures at and soon after the diagnosis
DiMeglio, Linda A., Evans-Molina, Carmella, Geyer, Susan, Ismail, Heba M., Libman, Ingrid M., Liu, Yuk-Fun, Palmer, Jerry P., Rafkin, Lisa E., Skyler, Jay S., Sosenko, Jay M.   +9 more
core   +3 more sources

Alamethicin self-assembling in lipid membranes: concentration dependence from pulsed EPR of spin labels [PDF]

, 2018
The antimicrobial action of the peptide antibiotic alamethicin (Alm) is commonly related to peptide self-assembling resulting in the formation of voltage-dependent channels in bacterial membranes, which induces ion permeation.
De Zotti, Marta, Dzuba, Sergei A, Formaggio, Fernando, Syryamina, Victoria N, Toniolo, Claudio   +4 more
core   +1 more source

Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94 [PDF]

, 2004
Because the stress protein GRP94 can augment presentation of peptides to T cells, it is important to define how it, as well as all other HSP90 family members, binds peptides.
Argon, Baker-LePain, Baker-LePain, Binder, Blachere, Blond-Elguindi, Breloer, Burkholder, Collins, Fontana, Gragerov, Imarai, Ishii, Kalkum, Liu, Meng, Nieland, Prendergast, Prodromou, Prodromou, Prodromou, Rai, Robert, Roe, Schagger, Scheibel, Scheibel, Schneidman-Duhovny, Schulte, Shields, Shields, Singh-Jasuja, Slavik, Smith, Soldano, Spee, Stebbins, Suto, Tamura, Vogen, Wassenberg, Wearsch, Wearsch, Zhang, Zhu   +44 more
core   +1 more source

Antibacterial Peptides [PDF]

Antibiotics, 2020
As natural host defense compounds produced by numerous prokaryotic and eukaryotic life forms, antimicrobial peptides (AMPs) are now emerging as solid candidate chemotherapeutic drugs to fight against the various types of pathogenic Gram-positive and Gram-negative bacteria, especially those resistant to current antibiotics [...]
openaire   +5 more sources

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy

Journal of Hematology & Oncology, 2018
Background The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer.
Erhao Zhang, Peiwei Yang, Jieyi Gu, Heming Wu, Xiaowei Chi, Chen Liu, Ying Wang, Jianpeng Xue, Weiyan Qi, Qingbo Sun, Shengnan Zhang, Jialiang Hu, Hanmei Xu   +12 more
doaj   +1 more source

Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3 [PDF]

, 1992
To reduce the opportunities for human immunodeficiency virus type 1 (HIV-1) to evade vaccine induced immunity, the development of subunit vaccines must focus on the characterization of immunogenic epitopes, which are major targets for the immune system ...
Böltz, T., Fliessbach, H., Modrow, Susanne, Niedrig, M., von Brunn, A., Wagner, R., Wolf, Hans J.   +6 more
core   +1 more source

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]

, 2006
Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Davies, M.N., Drew, M.G.B., Flower, D.R., Hattotuwagama, C.K., Moss, David S.   +4 more
core   +3 more sources

Training self-supervised peptide sequence models on artificially chopped proteins [PDF]

arXiv, 2022
Representation learning for proteins has primarily focused on the global understanding of protein sequences regardless of their length. However, shorter proteins (known as peptides) take on distinct structures and functions compared to their longer counterparts. Unfortunately, there are not as many naturally occurring peptides available to be sequenced
arxiv  

N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19

Advances in Pharmacological and Pharmaceutical Sciences, 2022
The airway epithelial glycocalyx plays an important role in preventing severe acute respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial glycocalyx contributes to vascular permeability and tone, as well as modulating ...
Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson   +3 more
doaj   +1 more source