Results 181 to 190 of about 2,035,646 (256)

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Synthetic KL4 peptide as new carrier of siRNA therapeutics for pulmonary delivery

, 2017
Small interfering RNA (siRNA) has great potential for the treatment of various respiratory diseases through RNA interference (RNAi), but their clinical application is hindered by the lack of a safe and effective pulmonary delivery system.
Chow, MYT, Lam, JKW, Qiu, Y
core  

Poly(lactic-co-glycolic acid) nanoparticles and microparticles for peptide delivery: release mechanisms and controlling factors. [PDF]

ADMET DMPK
Eshaghi M, Dehghani M, Abedi A, Moghaddam MM, Taheri RA.   +4 more
europepmc   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

3D Printing of Self‐Healing Polymers by Material Extrusion: A Process‐Centric Review of Setups, Parameters, and Applications

Advanced Robotics Research, EarlyView.
This review highlights recent advances in material extrusion 3D printing of self‐healing polymers, focusing on the interplay between material chemistry, rheology, hardware customization, and process optimization. Filament‐ and ink‐based extrusion strategies, multimaterial architectures, and postprocessing approaches are discussed for applications in ...
Antonio Pavone, Gianni Stano, Gianluca Percoco   +2 more
wiley   +1 more source

Repurpose the antimicrobial peptide Buforin II for plasmid transformation into Escherichia coli

CTU Journal of Innovation and Sustainable Development
Antimicrobial peptides Buforin II, derived from histone H2A, demonstrates strong cell-penetrating activity without cell lysis and strong affinity for internal cellular nucleic acids, making it a potential candidate for macromolecule delivery into ...
Thanh Ngoc Nguyen, Le Minh Bui
doaj  

An effort to enhance the clinical translatability of caprate-based tablet formulations in gastric peptide delivery. [PDF]

Drug Deliv Transl Res
Bardonnet PL, Niu Z, Pessi J, Kazakou M, Raptis K, McCabe R, Toftlev A, Rebollo R, Wang Z, Fan L, Mortensen NR, Bardtrum L, Andersson V, Wahlund PO, Norrman M, Benie AJ, Wu JX, Sauter M, Zara D, Christophersen P, Sassene PJ.   +20 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

pH-responsive polymeric nanoparticles for peptide delivery: Synergistic STING pathway activation enhances tumor immunotherapy. [PDF]

Int J Pharm X
Rui M, Tang H, Gao L, Hu Y, Liang W, Li Y, Feng C.   +6 more
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source