Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles
Advanced Functional Materials, EarlyView.Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati +2 more
wiley +1 more source
Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design. [PDF]
ACS Nano, 2019 Son J +6 more
europepmc +1 more source
Advanced Functional Materials, EarlyView.A robust solid‐state protein junction with a semi‐transparent eC/Au electrode allows photoexcitation of the bacterio‐rhodopsin, bR layer, to isomerize the bR retinal. The resulting photo‐response shows the protein is functional in the solid‐state junction.
Shailendra K. Saxena +5 more
wiley +1 more source
Structure-based inhibitory peptide design targeting peptide-substrate binding site in EGFR tyrosine kinase. [PDF]
PLoS One, 2019 Tavakoli F, Ganjalikhany MR.
europepmc +1 more source
Mechanically Stable and Tunable Photoactivated Peptide‐Based Hydrogels for Soft Tissue Adhesion
Advanced Functional Materials, EarlyView.A collagen‐like peptide hydrogel platform is developed using supramolecular self‐assembly and light‐triggered crosslinking. It creates mechanically stable, tunable hydrogels with cytocompatibility and biodegradability, making them potential soft tissue adhesives.
Alex Ross +8 more
wiley +1 more source
Rapid and accurate structure-based therapeutic peptide design using GPU accelerated thermodynamic integration. [PDF]
Proteins, 2019 Garton M +6 more
europepmc +1 more source
Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction
Advanced Functional Materials, EarlyView.Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch +13 more
wiley +1 more source
Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel
Advanced Functional Materials, EarlyView.This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar +5 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng +16 more
wiley +1 more source
Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma [PDF]
, 2019 Artyomov, Maxim N. +15 more
core +1 more source