Results 251 to 260 of about 935,022 (285)
Some of the next articles are maybe not open access.
Patenting computer-designed peptides
Journal of Computer-Aided Molecular Design, 1998The problem of designing new peptides that possess specific properties, such as bactericidal activity, is of wide interest. Recently, attention has focused on the use of Computer-Aided Molecular Design techniques in parallel with more traditional 'synthesise and test' methods.
S, Patel +3 more
openaire +2 more sources
Designing peptide based nanomaterials
Chemical Society Reviews, 2008This tutorial review looks at the design rules that allow peptides to be exploited as building blocks for the assembly of nanomaterials. These design rules are either derived by copying nature (alpha-helix, beta-sheet) or may exploit entirely new designs based on peptide derivatives (peptide amphiphiles, pi-stacking systems).
Ulijn, Rein V., Smith, Andrew M.
openaire +3 more sources
Molecular designer self-assembling peptides
Chemical Society Reviews, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiaojun, Zhao, Shuguang, Zhang
openaire +2 more sources
Pep–Whisperer: Inhibitory peptide design
Proteins: Structure, Function, and Bioinformatics, 2022Abstract Designing peptides for protein–protein interaction inhibition is of significant interest in computer‐aided drug design. Such inhibitory peptides could mimic and compete with the binding of the partner protein to the inhibition target.
Naama Hurwitz +2 more
openaire +2 more sources
Designing immunogenic peptides
Nature Chemical Biology, 2013Peptides fulfill many roles in immunology, yet none are more important than their role as immunogenic epitopes driving the adaptive immune response, our ultimate bulwark against infectious disease. Peptide epitopes are mediated primarily by their interaction with major histocompatibility complexes (T-cell epitopes) and antibodies (B-cell epitopes).
openaire +2 more sources
ChemInform, 2002
Peptides have become an increasingly important class of molecules in biochemistry, medicinal chemistry, and physiology. Many naturally occurring, physiologically relevant peptides function as hormones, neurotransmitters, cytokines, and growth factors.
Michael L. Moore, Gregory A. Grant
openaire +1 more source
Peptides have become an increasingly important class of molecules in biochemistry, medicinal chemistry, and physiology. Many naturally occurring, physiologically relevant peptides function as hormones, neurotransmitters, cytokines, and growth factors.
Michael L. Moore, Gregory A. Grant
openaire +1 more source
Trends in Pharmacological Sciences, 1994
During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
openaire +2 more sources
During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
openaire +2 more sources
2002
Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
openaire +2 more sources
Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
openaire +2 more sources
Helical peptide and protein design
Current Opinion in Chemical Biology, 1999The design of dimeric coiled-coils has ultimately led to novel applications, such as self-replicating peptide systems, whereas the structural features of the less common trimeric coiled-coil continue to be elucidated. Novel topologies have been discovered in designed proteins, as exemplified by the right-handed tetrameric coiled-coil and the inverted U
C, Micklatcher, J, Chmielewski
openaire +2 more sources
Multifunctional thermoresponsive designer peptide hydrogels
Acta Biomaterialia, 2017We report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming β-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an RGD peptide sequence via "click" chemistry.
Luis M, De Leon-Rodriguez +5 more
openaire +2 more sources