Results 261 to 270 of about 935,022 (285)

Designer Self‐Assembling Peptide Materials

Macromolecular Bioscience, 2007
AbstractUnderstanding of macromolecular materials at the molecular level is becoming increasingly important for a new generation of nanomaterials for nanobiotechnology and other disciplines, namely, the design, synthesis, and fabrication of nanodevices at the molecular scale from bottom up.
Xiaojun, Zhao, Shuguang, Zhang
openaire   +2 more sources

Computational design of peptide ligands

Trends in Biotechnology, 2011
Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this ...
Peter, Vanhee, Almer M, van der Sloot, Erik, Verschueren, Luis, Serrano, Frederic, Rousseau, Joost, Schymkowitz   +5 more
openaire   +2 more sources

Multidimensional Design of Anticancer Peptides

Angewandte Chemie International Edition, 2015
AbstractThe computer‐assisted design and optimization of peptides with selective cancer cell killing activity was achieved through merging the features of anticancer peptides, cell‐penetrating peptides, and tumor‐homing peptides. Machine‐learning classifiers identified candidate peptides that possess the predicted properties.
Lin YC, Lim YF, Russo E, Schneider P, Bolliger L, Edenharter A, Altmann KH, Halin C, Hiss JA, Schneider G   +9 more
openaire   +2 more sources

A Designed β-Hairpin Peptide

Biochemical and Biophysical Research Communications, 1995
A synthetic octapeptide, Boc-Leu-Val-Val-D-Pro-Gly-Leu-Val-Val-OMe (1) has been designed as a model for a beta-hairpin conformation. Circular dichroism spectra in various organic solvents reveal a single negative band at 214-217 nm consistent with beta-sheet structures.
Awasthi, Satish K, Raghothama, S, Balaram, P   +2 more
openaire   +2 more sources

Designer Peptides: Learning from Nature

Current Pharmaceutical Design, 2009
Recent advances in designing peptide ligands for therapeutic targets are making peptides an attractive alternative to small molecules and proteins. It is now common to see peptides developed with affinities comparable to antibodies and specificities much better than small molecules or antibodies.
A, Shrivastava, A D, Nunn, M F, Tweedle
openaire   +2 more sources

Design of metal ion binding peptides

Biopolymers, 1995
AbstractTwo cyclic and branched peptides (PLA and AZU) were synthesized with the aim of reproducing the active site of the blue copper proteins plastocyanin and azurin. Both peptides, designed on the basis of the x‐ray structures of Poplar plastocyanin and Alcaligenes denitrificans azurin.
R. FATTORUSSO, G. MORELLI, LOMBARDI, ANGELINA, NASTRI, FLAVIA, O. MAGLIO, D'AURIA, GABRIELLA, C. PEDONE, PAVONE, VINCENZO   +7 more
openaire   +4 more sources

Carbohydrates in peptide and protein design

Peptide Science, 2005
AbstractMonosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and, to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g.,
Jensen, Knud J., Brask, Jesper
openaire   +2 more sources

Multiple Antigenic Peptides Designed to Structurally Related Drosophila Peptides

Peptides, 1997
We have isolated TDVDHVFLRFamide (DMS), FDDYGHMRFamide (DSK), and DPKQDFMRFamide from Drosophila melanogaster. These peptides, structurally related by a common C-terminus -XRFamide, where X = L or M, are encoded by three different genes. To determine cellular expression, we have generated antisera to multiple antigenic peptides and performed double ...
R, Nichols, J, McCormick, I, Lim
openaire   +2 more sources

Computational Design of Peptide Assemblies

Journal of Chemical Theory and Computation
With the ongoing development of peptide self-assembling materials, there is growing interest in exploring novel functional peptide sequences. From short peptides to long polypeptides, as the functionality increases, the sequence space is also expanding exponentially.
Jiwei Min, Xi Rong, Jiaxing Zhang, Rongxin Su, Yuefei Wang, Wei Qi   +5 more
openaire   +2 more sources

Peptide Bionanomaterials

2023
Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach.
openaire   +2 more sources