Results 251 to 260 of about 53,655 (285)

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Injectable pH-responsive polypeptide hydrogels for local delivery of doxorubicin. [PDF]

Nanoscale Adv
Guo Y, Chen Y, Wu Y, Zhu Y, Luo S, Shen J, Luo Y.   +6 more
europepmc   +1 more source

Dilute but Dense – Reversible Crosslinking Enables Water‐Rich (Bio)polymer Condensates

Advanced Science, EarlyView.
Reversible crosslinking between two types of (bio)polymers drives liquid–liquid phase separation even in good solvent. The arrangement of binding motifs controls condensate formation and density, and internal network structure. Simulations and theory reveal a closed‐loop coexistence phase diagram at very low monomer concentrations and re‐entrant ...
Xinxiang Chen, Jude Ann Vishnu, Pol Besenius, Julian König, Friederike Schmid   +4 more
wiley   +1 more source

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Gram-selective antibacterial peptide hydrogels

Biomaterials Science, 2022
In vitroandin vivostudies indicated that the antimicrobial peptide (AMP) hydrogels IK1 and IK4 specifically targeted Gram-positive and Gram-negative bacteria, respectively, while IK3 was broad-spectrum.
Yangqian Hou, Tingyuan Tan, Zhen Guo, Yuwen Ji, Jun Hu, Yi Zhang   +5 more
openaire   +2 more sources

Antimicrobial d-Peptide Hydrogels

ACS Biomaterials Science & Engineering, 2021
Biofilms are widely involved in human lives, such as in medical infection, environmental remediation, and industrial processes. However, the control of the biofilm has still been a challenge because of its strong drug resistance. Here, we designed and synthesized an amphipathic antimicrobial peptide (Ac-DKDHDHDQDKDLDVDFDFDADK-NH2 (KKd-11)) that was ...
Zhen Guo, Yujiao Wang, Tingyuan Tan, Yuwen Ji, Jun Hu, Yi Zhang   +5 more
openaire   +2 more sources

Self-healing cyclic peptide hydrogels

Journal of Materials Chemistry B, 2023
The structural design principles of cyclic peptides-based hydrogels are introduced. The resulting soft materials exhibited self-healing capabilities.
Alfonso Bayón-Fernández, Alejandro Méndez-Ardoy, Carmen Alvarez-Lorenzo, Juan R. Granja, Javier Montenegro   +4 more
openaire   +2 more sources

Multifunctional thermoresponsive designer peptide hydrogels

Acta Biomaterialia, 2017
We report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming β-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an RGD peptide sequence via "click" chemistry.
Luis M, De Leon-Rodriguez, Yacine, Hemar, Guang, Mo, Alok K, Mitra, Jillian, Cornish, Margaret A, Brimble   +5 more
openaire   +2 more sources