Results 41 to 50 of about 1,021,016 (260)

Supramolecular enzyme-mimicking catalysts self-assembled from peptides

iScience, 2023
Summary: Natural enzymes catalyze biochemical transformations in superior catalytic efficiency and remarkable substrate specificity. The excellent catalytic repertoire of enzymes is attributed to the sophisticated chemical structures of their active ...
Qing Liu, Akinori Kuzuya, Zhen-Gang Wang
doaj   +1 more source

Target identification strategies in plant chemical biology [PDF]

, 2014
The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies.
Dejonghe, Wim, Russinova, Eugenia
core   +2 more sources

Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway

Biomolecules, 2020
The N-degron pathway is a proteolytic system in which a single N-terminal amino acid acts as a determinant of protein degradation. Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N ...
Joon Sung Park, Jae-Young Lee, Yen Thi Kim Nguyen, Nae-Won Kang, Eun Kyung Oh, Dong Man Jang, Hyun-Jung Kim, Dae-Duk Kim, Byung Woo Han   +8 more
doaj   +1 more source

Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells

Viruses, 2022
Staphylococcus aureus is a major causative agent of bovine mastitis, a disease considered one of the most economically devastating in the dairy sector.
Anja P. Keller, Shera Ly, Steven Daetwyler, Fritz Eichenseher, Martin J. Loessner, Mathias Schmelcher   +5 more
doaj   +1 more source

Crystal Structure of Imaginal Disc Growth Factor-2 [PDF]

, 2002
Imaginal disc growth factor-2 (IDGF-2) is a member of a recently described family of Drosophila melanogaster-soluble polypeptide growth factors that promote cell proliferation in imaginal discs.
Llera, Andrea Sabina, Mariuzza, Roy A., Tormo, José, Varela, Paloma F.   +3 more
core   +1 more source

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile

Microbial Cell, 2018
Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj   +1 more source

Proteome readjustments in the apoplastic space of Arabidopsis thaliana ggt1 mutant leaves exposed to UV-B radiation [PDF]

, 2015
Ultraviolet-B radiation acts as an environmental stimulus, but in high doses it has detrimental effects on plant metabolism. Plasma membranes represent a major target for ROS generated by this harmful radiation.
ARRIGONI, GIORGIO, FABREGA PRATS, MARTA, GIARETTA, SABRINA, Leonard Ebinezer Barnabas, MASI, ANTONIO, PIVATO, MICAELA, PRASAD, DINESH, Syed M. M. Mehdi, TRENTIN, ANNA RITA   +8 more
core   +2 more sources

Cathepsin E (EC 3.4.23.34) — a review

Folia Histochemica et Cytobiologica, 2012
Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska, Marek Gacko, Michał Chlabicz, Radosław Łapiński   +3 more
doaj   +1 more source

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

mBio, 2023
The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks.
Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher   +14 more
doaj   +1 more source

Rahnella sp., a Dominant Symbiont of the Core Gut Bacteriome of Dendroctonus Species, Has Metabolic Capacity to Degrade Xylan by Bifunctional Xylanase-Ferulic Acid Esterase

Frontiers in Microbiology, 2022
Rahnella sp. ChDrAdgB13 is a dominant member of the gut bacterial core of species of the genus Dendroctonus, which is one of the most destructive pine forest bark beetles. The objectives of this study were identified in Rahnella sp. ChDrAdgB13 genome the
Rosa María Pineda-Mendoza, Gerardo Zúñiga, María Fernanda López, María Eugenia Hidalgo-Lara, Alejandro Santiago-Hernández, Azucena López-López, Flor N. Rivera Orduña, Claudia Cano-Ramírez   +7 more
doaj   +1 more source