Prediction of Hemolysis Tendency of Peptides using a Reliable Evaluation Method [PDF]
arXiv, 2020 There are numerous peptides discovered through past decades, which exhibit antimicrobial and anti-cancerous tendencies. Due to these reasons, peptides are supposed to be sound therapeutic candidates. Some peptides can pose low metabolic stability, high toxicity and high hemolity of peptides.
arxiv
Docking Peptides into HIV/FIV Protease with Deep Learning and Focused Peptide Docking Methods [PDF]
arXiv, 2023 Molecular docking is a structure-based computational drug design technique for predicting the interaction between a small molecule (ligand) and a macromolecule (receptor). Over the past three decades various docking software programs have been developed, mostly for drug-like molecules.
arxiv
Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell penetrating peptides [PDF]
Biophysical Journal, Volume 97, Issue 7, 7 October 2009, Pages
1917-1925, 2009 Recent molecular dynamics simulations (Herce and Garcia, PNAS, 104: 20805 (2007)) have suggested that the arginine-rich HIV Tat peptides might be able to translocate by destabilizing and inducing transient pores in phospholipid bilayers. In this pathway for peptide translocation, arginine residues play a fundamental role not only in the binding of the ...
arxiv +1 more source
eLifeOrchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci +6 more
doaj +1 more source
BMC Genomics, 2017 Background Trichoderma harzianum is used in biotechnology applications due to its ability to produce powerful enzymes for the conversion of lignocellulosic substrates into soluble sugars.
Jaire Alves Ferreira Filho +4 more
doaj +1 more source
Peptide Hydrolases of Lactobacillus helveticus and Lactobacillus delbrueckii ssp. bulgaricus
, 1991 Lactobacillus helveticus CNRZ 32 had more aminopeptidase and dipeptidase activity than did Lactobacillus helveticus ATCC 10797 or Lactobacillus delbrueckii ssp. bulgaricus ATCC 12278, whereas L. helveticus ATCC 10797 was most proteolytic (100%), followed
Noraini M. Khalid +2 more
semanticscholar +1 more source
Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology
Microbial Cell Factories, 2021 Background The oleaginous yeast Cutaneotrichosporon oleaginosus represents one of the most promising microbial platforms for resource-efficient and scalable lipid production, with the capacity to accept a wide range of carbohydrates encapsulated in ...
Tobias Fuchs +10 more
doaj +1 more source
Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study [PDF]
arXiv, 2020 2019-nCoV is a novel coronavirus was isolated and identified in 2019 in Wuhan, China. On 17th February and according to world health organization, a number of 71 429 confirmed cases worldwide, among them 2162 new cases recorded in the last 24 hours. There is no drug or vaccine for human and animal coronavirus.
arxiv
Influence of pH and sequence in peptide aggregation via molecular simulation [PDF]
, 2015 We employ a recently developed coarse-grained model for peptides and proteins where the effect of pH is automatically included. We explore the effect of pH in the aggregation process of the amyloidogenic peptide KTVIIE and two related sequences, using three different pH environments. Simulations using large systems (24 peptides chains per box) allow us
arxiv +1 more source
Concerted Rolling and Membrane Penetration Revealed by Atomistic Simulations of Antimicrobial Peptides [PDF]
arXiv, 2021 Short peptides with antimicrobial activity have therapeutic potential for treating bacterial infections. Mechanisms of actions for antimicrobial peptides require binding the biological membrane of their target, which often represents a key mechanistic step.
arxiv