Results 21 to 30 of about 215 (167)

Cathepsin E (EC 3.4.23.34) — a review

Folia Histochemica et Cytobiologica, 2012
Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska, Marek Gacko, Michał Chlabicz, Radosław Łapiński   +3 more
doaj   +1 more source

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

mBio, 2023
The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks.
Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher   +14 more
doaj   +1 more source

Rahnella sp., a Dominant Symbiont of the Core Gut Bacteriome of Dendroctonus Species, Has Metabolic Capacity to Degrade Xylan by Bifunctional Xylanase-Ferulic Acid Esterase

Frontiers in Microbiology, 2022
Rahnella sp. ChDrAdgB13 is a dominant member of the gut bacterial core of species of the genus Dendroctonus, which is one of the most destructive pine forest bark beetles. The objectives of this study were identified in Rahnella sp. ChDrAdgB13 genome the
Rosa María Pineda-Mendoza, Gerardo Zúñiga, María Fernanda López, María Eugenia Hidalgo-Lara, Alejandro Santiago-Hernández, Azucena López-López, Flor N. Rivera Orduña, Claudia Cano-Ramírez   +7 more
doaj   +1 more source

Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection

Инфекция и иммунитет, 2021
The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes.
M. A. Zhuraeva, V. A. Aleinik, N. D. Ashuralieva, D. S. Halikova, J. B. Ravzatov, B. K. Abdulazizhozhyv   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Induced Chronic Rhinosinusitis in Rats Leads to Secondary Changes in Sinonasal Microbiota

Laryngoscope Investigative Otolaryngology
Background The microbiota may play a role in maintaining and perpetuating inflammation in chronic rhinosinusitis (CRS). This study aimed to induce CRS in rats and evaluate microbiota composition compared to controls. Methods Sixteen male Wistar rats were
Fernanda Barriga‐Chambi, Fabricio Ccami‐Bernal, Frank Zela‐Coila, Marial Hernandez‐Caycho, Claudia Mares‐Cuadros, Marcos Salas‐Palma, Jorge Ballón‐Echegaray, Renato Torres   +7 more
doaj   +1 more source