Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis. [PDF]
PLoS ONE, 2013 The development of suitable methods to deliver peptides specifically to the endoplasmic reticulum (ER) can provide some potential therapeutic applications of such peptides.
Hui-Chun Yu +7 more
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Inhibition of Staphylococcus aureus biofilm formation by gurmarin, a plant-derived cyclic peptide [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Staphylococcus aureus (Sa) is an opportunistic pathogen capable of causing various infections ranging from superficial skin infections to life-threatening severe diseases including pneumonia and sepsis.
Adeline W. Chang +5 more
doaj +2 more sources
Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM [PDF]
eLifeOrchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci +6 more
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Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection [PDF]
Инфекция и иммунитет, 2021 The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes.
M. A. Zhuraeva +5 more
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Isolation of Moderately Halophilic Bacteria in Saline Environments of Sonora State Searching for Proteolytic Hydrolases [PDF]
Open Agriculture, 2018 The aim of the study was to isolate moderately halophilic bacteria that produce proteolytic enzymes with industrial biotechnological value. Screening of halophiles from various saline habitats, led to the isolation of 210 moderately halophilic bacteria ...
Corral Juan Carlos Coronado +6 more
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Detecting and identifying glycoside hydrolases using cyclophellitol-derived activity-based probes [PDF]
, 2022 The ability to detect active enzymes in a complex mixture of folded proteins (e.g., secretome, cell lysate) generally relies on observations of catalytic ability, necessitating the development of an activity assay that is compatible with the sample and ...
Overkleeft, H.S. +5 more
core +3 more sources
Biomolecules, 2020 Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD.
Fernando Valenzuela +6 more
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Specificity determinants of acylaminoacyl‐peptide hydrolase [PDF]
Protein Science, 1992 AbstractIn an attempt to explore how specific features of the substrate's primary structure may affect the activity of rabbit muscle acylaminoacyl‐peptide hydrolase (EC 3.4.19.1), a number of acetylated peptides containing specific amino acid replacements in specific positions were prepared and compared as substrates for the hydrolase.
R G, Krishna, F, Wold
openaire +2 more sources
Conjugating Catalytic Polyproline Fragments with a Self-Assembling Peptide Produces Efficient Artificial Hydrolases [PDF]
, 2020 A polyproline fragment containing a catalytic dyad of His–His or Ser–His was coupled with a self-assembling peptide MAX1 to design new hydrolases (H2H5 and H2S5) for catalyzing ester hydrolysis. Circular dichroism measurements indicated that the peptides
Chi-Ching Yu +5 more
core +1 more source
Preparation and Analysis of Crude Autolytic Enzyme Extracts from Staphylococcus aureus
Bio-Protocol, 2015 The metabolism of the cell surface during bacterial cell division involves synthesis and degradation of peptidoglycan (PGN), the major component of the bacterial cell wall.
Filipa Vaz, Sérgio Filipe
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