Results 41 to 50 of about 60,986 (298)

Prediction of peptidoglycan hydrolases- a new class of antibacterial proteins [PDF]

, 2016
Comparison of performance of the three approaches using known 250 peptidoglycan hydrolases.
Ashok K. Sharma, Darshan B. Dhakan, Harish K., Sanjiv Kumar, Vineet K. Sharma   +4 more
core   +10 more sources

The peptide hydrolase system of Lactobacillus reuteri

International Journal of Food Microbiology, 2001
Peptide hydrolase system of Lactobacillus reuteri CRL 1098, a lactic acid bacteria of sourdough origin, was investigated. This microorganism has a broad range of peptidases consisting of an active aminopeptidase, X-Prolyl-dipeptidylaminopeptidase, dipeptidase and tripeptidase.
Rollan, Graciela Celestina, Font, Graciela Maria   +1 more
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multi-omic Analyses of Extensively Decayed Pinus contorta Reveal Expression of a Diverse Array of Lignocellulose-Degrading Enzymes. [PDF]

, 2018
Fungi play a key role cycling nutrients in forest ecosystems, but the mechanisms remain uncertain. To clarify the enzymatic processes involved in wood decomposition, the metatranscriptomics and metaproteomics of extensively decayed lodgepole pine were ...
Barry, Kerrie, Bhatnagar, Jennifer M, Cullen, Dan, Fauchery, Laure, Gaskell, Jill, Grigoriev, Igor V, Hori, Chiaki, Kohler, Annegret, Lail, Kathleen, Martin, Francis, Peng, Yi, Sabat, Grzegorz, Stewart, Philip E, Zeiner, Carolyn A   +13 more
core  

Model for eukaryotic tail-anchored protein binding based on the structure of Get3 [PDF]

, 2009
The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and include many essential proteins, such as ...
Ahmadian, Borgese, Boskovic, C. J. M. Suloway, Ching, Freymann, Georgiadis, Halic, Hann, Hemmingsson, J. W. Chartron, Jonikas, Kao, Koonin, Kutay, Lukasik, Lutkenhaus, M. Zaslaver, Milburn, Montoya, Netz, Ogura, Scheffzek, Schindelin, Schlessman, Schuldiner, Schuldiner, Shen, Sprang, Stefanovic, Tseng, W. M. Clemons, Wang, Zhou, Z    iga   +34 more
core   +3 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Cloning, preparation and preliminary crystallographic studies of penicillin V acylase autoproteolytic processing mutants [PDF]

, 2005
The crystallization of three catalytically inactive mutants of penicillin Vacylase (PVA) from Bacillus sphaericus in precursor and processed forms is reported.
Brannigan, J A, Chandra, P M, Dodson, G G, Prabhune, A, Pundle, A, Suresh, C G, Turkenburg, J P   +6 more
core   +2 more sources

The Peptide Hydrolase System of the Leuconostoc

Journal of Food Protection, 1990
The intracellular peptide hydrolase activities of Leuconostoc species were determined using various aminopeptidase, dipeptidase, carboxypeptidase substrates, and casein. The activities were separated by disc gel electrophoresis. All strains had aminopeptidase activity as determined with amino acid ß-napthylamides and dipeptidase.
H, El-Shafei, M, El-Soda, N, Ezzat
openaire   +2 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source