Results 51 to 60 of about 60,986 (298)

Computational analysis of sequential and structural variations in stromelysins as an insight towards matrix metalloproteinase research

Informatics in Medicine Unlocked, 2018
Matrix metalloproteinases are zinc-dependent protein and peptide hydrolases. They are broadly involved in metabolic regulation through both extensive protein degradation and selective peptide-bond hydrolysis.
Beutline Malgija, Host Antony David Rajendran, Uma Maheswari, Nivetha Sarah Ebenezer, Joyce Priyakumari, Shanmughavel Piramanayagam   +5 more
doaj   +1 more source

Substrate specificity and structural investigation into PepO and PepW : two peptidases from Lactobacillus rhamnosus : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2005
The proteolytic systems of lactic acid bacteria have important roles in the maturation and flavour development of cheese. Lactic acid bacteria pepetidases contribute to the taste of cheese through the production of low-molecular weight peptides and free ...
Yates, Karen Maree
core  

Autophagy and rheumatoid arthritis: Current knowledges and future perspectives [PDF]

, 2018
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, Franco, Manuela Di, Novelli, Lucia, Perricone, Carlo, Spinelli, Francesca Romana, Valesini, Guido, Vomero, Marta   +10 more
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]

, 2003
A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Basten, E.J.W., Dekker, P.J.T., Schaap, P.J.   +2 more
core   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Induced Chronic Rhinosinusitis in Rats Leads to Secondary Changes in Sinonasal Microbiota

Laryngoscope Investigative Otolaryngology
Background The microbiota may play a role in maintaining and perpetuating inflammation in chronic rhinosinusitis (CRS). This study aimed to induce CRS in rats and evaluate microbiota composition compared to controls. Methods Sixteen male Wistar rats were
Fernanda Barriga‐Chambi, Fabricio Ccami‐Bernal, Frank Zela‐Coila, Marial Hernandez‐Caycho, Claudia Mares‐Cuadros, Marcos Salas‐Palma, Jorge Ballón‐Echegaray, Renato Torres   +7 more
doaj   +1 more source

Reassessing the substrate specificities of the major Staphylococcus aureus peptidoglycan hydrolases lysostaphin and LytM

eLife
Orchestrated action of peptidoglycan (PG) synthetases and hydrolases is vital for bacterial growth and viability. Although the function of several PG synthetases and hydrolases is well understood, the function, regulation, and mechanism of action of PG ...
Lina Antenucci, Salla Virtanen, Chandan Thapa, Minne Jartti, Ilona Pitkänen, Helena Tossavainen, Perttu Permi   +6 more
doaj   +1 more source

Plant secretome proteomics

Frontiers in Plant Science, 2013
The plant secretome refers to the set of proteins secreted out of the plant cell into the surrounding extra-cellular space commonly referred to as the apoplast.
Erik eAlexandersson, Ali eAshfaq, Svante eResjö, Erik eAndreasson   +3 more
doaj   +1 more source

Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases [PDF]

, 2013
Background: Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively. The excretory-secretory (ES) molecules produced and presented at the parasite-host interface during the different
Deforce, Dieter, Dhaenens, Maarten, Gasser, Robin B, Geldhof, Peter, Jex, Aaron R, Van Steendam, Katleen, Vlaminck, Johnny, Wang, Tao   +7 more
core   +5 more sources