Results 71 to 80 of about 572,875 (296)

A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis

Advanced Science, EarlyView.
This study identifies GAP2, a bioactive polysaccharide fraction derived from Ganoderma applanatum, as a postbiotic inducer that repairs intestinal barrier damage in a gut microbiota‐dependent manner. GAP2 enriches Phocaeicola vulgatus, which degrades GAP2 and promotes tridecylic acid production, triggering Rho/CDC42 signaling and tight‐junction ...
Chuan Zhang, Miaoyu Li, Tiantian Li, Xiaojie Zang, Haiyang Shi, Yaru Liu, Chengcheng Zhang, Jianxin Zhao, Qixiao Zhai, Wei Chen, Fengwei Tian   +10 more
wiley   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

Microbial Cell Factories, 2021
Background The oleaginous yeast Cutaneotrichosporon oleaginosus represents one of the most promising microbial platforms for resource-efficient and scalable lipid production, with the capacity to accept a wide range of carbohydrates encapsulated in ...
Tobias Fuchs, Felix Melcher, Zora Selina Rerop, Jan Lorenzen, Pariya Shaigani, Dania Awad, Martina Haack, Sophia Alice Prem, Mahmoud Masri, Norbert Mehlmer, Thomas B. Brueck   +10 more
doaj   +1 more source

Hydrolases involving lignocellulose degradation from various microorganisms.

, 1997
Hydrolases involving lignocellulose degradation from various ...
Yongxin (Robert). Zhao (7996985)
core   +4 more sources

Peptide hydrolase activities of the mucosa of human small intestine [PDF]

Journal of Clinical Investigation, 1969
Few studies have been published on peptide hydrolase activities of human small intestine mucosa. We developed methods to screen tissue extracts for such enzymes and to quantitate hydrolase activities for dipeptides containing the aromatic amino acid L-phenylalanine.
W D, Heizer, L, Laster
openaire   +2 more sources

Variability of expression of trypsyn peptide hydrolases in Drosophila virilis laboratory

, 2016
Проведено дослідження активності трипсиноподібних пептидгідролаз личинок, лялечок та імаго лабораторної популяції Drosophila virilis. Математично визначені кількісні показники активності ферменту: відносна та питома активність трипсиноподібних ...
Подзолкова, Юлія Юріївна
core   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

A GMR enzymatic assay for quantifying nuclease and peptidase activity

Frontiers in Bioengineering and Biotechnology
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bonds, glycosidic
Michael Sveiven, Ana K. Serrano, Joshua Rosenberg, Douglas J. Conrad, Drew A. Hall, Drew A. Hall, Anthony J. O’Donoghue   +6 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Isolation of Moderately Halophilic Bacteria in Saline Environments of Sonora State Searching for Proteolytic Hydrolases

Open Agriculture, 2018
The aim of the study was to isolate moderately halophilic bacteria that produce proteolytic enzymes with industrial biotechnological value. Screening of halophiles from various saline habitats, led to the isolation of 210 moderately halophilic bacteria ...
Corral Juan Carlos Coronado, de los Santos Villalobos Sergio, Barrgàn Lilia Arely Prado, Figueroa Juan Jose Buenrostro, Vásquez-Murrieta María Soledad, Alvarado María Isabel Estrada, Chávez Luis Alberto Cira   +6 more
doaj   +1 more source