Results 71 to 80 of about 497,366 (249)

Sequence‐Based and Functional Analysis for the Discovery of N‐Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut

MicrobiologyOpen
The role of bacterial glycosyl hydrolases (GHs) in degrading free human milk oligosaccharides is well documented. However, their activity on glycoconjugates is less well known.
Irene Boscá‐Sánchez, Jesús Rodríguez‐Díaz, María J. Yebra   +2 more
doaj   +1 more source

Identifying carbohydrate-active enzymes of Cutaneotrichosporon oleaginosus using systems biology

Microbial Cell Factories, 2021
Background The oleaginous yeast Cutaneotrichosporon oleaginosus represents one of the most promising microbial platforms for resource-efficient and scalable lipid production, with the capacity to accept a wide range of carbohydrates encapsulated in ...
Tobias Fuchs, Felix Melcher, Zora Selina Rerop, Jan Lorenzen, Pariya Shaigani, Dania Awad, Martina Haack, Sophia Alice Prem, Mahmoud Masri, Norbert Mehlmer, Thomas B. Brueck   +10 more
doaj   +1 more source

Peptide-conjugated micelles as a targeting nanocarrier for gene delivery

, 2017
The aim of this study was to develop peptide-conjugated micelles possessing epidermal growth factor receptor (EGFR) targeting ability for gene delivery.
Lin, Wen Jen;Chien, Wei Hsuan, 林文貞
core   +1 more source

Identification of Carbohydrate Metabolism Genes in the Metagenome of a Marine Biofilm Community Shown to Be Dominated by Gammaproteobacteria and Bacteroidetes [PDF]

, 2010
Polysaccharides are an important source of organic carbon in the marine environment and degradation of the insoluble and globally abundant cellulose is a major component of the marine carbon cycle.
Joint, IR, Edwards, JL, Connolly, J, Edwards, Jennifer L, Joint, Ian, McCarthy, Alan J, McDonald, James E; id_orcid, Darren L. Smith, Smith, Darren, Clive Edwards, Jennifer L. Edwards, McDonald, James, McDonald, JE, Edwards, C, James E. McDonald, Smith, DL, Edwards, Jennifer, Ian Joint, Smith, Darren L, Cox, MJ, Cox, Michael, Connolly, John, John Connolly, Michael J. Cox, McCarthy, AJ, McCarthy, Alan, Cox, Michael J; id_orcid, Edwards, Clive, Alan J. McCarthy   +28 more
core   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

A GMR enzymatic assay for quantifying nuclease and peptidase activity

Frontiers in Bioengineering and Biotechnology
Hydrolytic enzymes play crucial roles in cellular processes, and dysregulation of their activities is implicated in various physiological and pathological conditions. These enzymes cleave substrates such as peptide bonds, phosphodiester bonds, glycosidic
Michael Sveiven, Ana K. Serrano, Joshua Rosenberg, Douglas J. Conrad, Drew A. Hall, Drew A. Hall, Anthony J. O’Donoghue   +6 more
doaj   +1 more source

Isolation of Moderately Halophilic Bacteria in Saline Environments of Sonora State Searching for Proteolytic Hydrolases

Open Agriculture, 2018
The aim of the study was to isolate moderately halophilic bacteria that produce proteolytic enzymes with industrial biotechnological value. Screening of halophiles from various saline habitats, led to the isolation of 210 moderately halophilic bacteria ...
Corral Juan Carlos Coronado, de los Santos Villalobos Sergio, Barrgàn Lilia Arely Prado, Figueroa Juan Jose Buenrostro, Vásquez-Murrieta María Soledad, Alvarado María Isabel Estrada, Chávez Luis Alberto Cira   +6 more
doaj   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +1 more source

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]

, 2006
Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Hattotuwagama, C.K., Moss, David S., Davies, M.N., David S Moss, Drew, M.G.B., Channa K Hattotuwagama, Drew, Michael G.B., Flower, Darren R., Matthew N Davies, Hattotuwagama, Channa K., Davies, Matthew N., Michael GB Drew, Darren R Flower, Flower, D.R., Moss, D.S.   +14 more
core   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source