Results 81 to 90 of about 497,366 (249)
What’s the importance of peptidases in cancer? [PDF]
Einstein (São Paulo), 2009 A synonym for a successful tumor spread is a productive invasive cell migration, a process by which the extracellular matrix plays the role of substrate for cells to move and reach a secondary site.
Adriana Miti Nakahata +2 more
doaj
P. aeruginosa CtpA protease adopts a novel activation mechanism to initiate the proteolytic process
The EMBO JournalDuring bacterial cell growth, hydrolases cleave peptide cross-links between strands of the peptidoglycan sacculus to allow new strand insertion.
Hao-Chi Hsu +4 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Enzimas proteolíticas relacionadas con la enfermedad periodontal inflamatoria
Revista Cubana de Estomatología, 1998 La enfermedad periodontal inflamatoria ocasiona la destrucción de los tejidos que protegen y soportan al diente; es por eso de gran importancia el papel que pueden desempeñar las enzimas que sean capaces de degradar la matriz del tejido conectivo, como ...
Bárbara E. García Triana +3 more
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Frontiers in Microbiology, 2019 The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least constituted of peptidoglycan (PG) but also of (lipo)teichoic acids, various polysaccharides, polyglutamate and/or proteins. During bacterial growth and division, there
Aurore Vermassen +5 more
doaj +1 more source
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion
Advanced ScienceThe assembly line biosynthesis of the powerful anticancer‐antiviral didemnin cyclic peptides is proposed to follow a prodrug release mechanism in Tristella bacteria.
Xiaolin Zou +12 more
doaj +1 more source
Microbiology Indonesia, 2017 Lipases (EC 3.1.1.3) are classified as hydrolases that hydrolyze lipids. These enzymes have potential application in biotechnology and industrial process. In previous study we have cloned the synthetic Rhizomucor miehei lipase gene using the vector pUC57
doaj +1 more source
Journal of Lipid Research, 2010 LDL particles that enter the arterial intima become exposed to proteolytic and lipolytic modifications. The extracellular hydrolases potentially involved in LDL modification include proteolytic enzymes, such as chymase, cathepsin S, and plasmin, and ...
Riia Plihtari +3 more
doaj +1 more source
Optimization-Based Peptide Mass Fingerprinting for Protein Mixture Identification [PDF]
, 2008 *Motivation:* In current proteome research, peptide sequencing is probably the most widely used method for protein mixture identification. However, this peptide-centric method has its own disadvantages such as the immense volume of tandem Mass ...
Zengyou He +5 more
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