Results 81 to 90 of about 572,875 (296)

Discovery and Engineering of Enzymes for Peptide Synthesis and Activation

, 2016
Enzymes are widely used for peptide synthesis, both for coupling and for terminal activation and modification. Broad-specificity proteases of different mechanistic classes can be used for C-terminal activation and peptide coupling reactions, whereas ...
Wu, Bian, Ana Toplak, Janssen, Dick B., Dick B. Janssen, Muhammad I. Arif, Bian Wu, Arif, Muhammad I., Toplak, Ana   +7 more
core   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Peptide-conjugated micelles as a targeting nanocarrier for gene delivery

, 2017
The aim of this study was to develop peptide-conjugated micelles possessing epidermal growth factor receptor (EGFR) targeting ability for gene delivery.
Lin, Wen Jen;Chien, Wei Hsuan, 林文貞
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

What’s the importance of peptidases in cancer? [PDF]

Einstein (São Paulo), 2009
A synonym for a successful tumor spread is a productive invasive cell migration, a process by which the extracellular matrix plays the role of substrate for cells to move and reach a secondary site.
Adriana Miti Nakahata, Maria Luiza Vilela Oliva, Oswaldo Keith Okamoto   +2 more
doaj  

Peptide hydrolases in senescing ragi leaves

Biologia Plantarum, 1987
Two peptide hydrolases — one active at pH 7.0 and the other at pH 3.4 (SH-dependent) were detected in ragi (Eleusine coracana Gaertn. cv. PR 202) leaves. The absolute activities of both acid and neutral peptide hydrolases were move or less stable in attached leaves and exhibited a mild rise in excised leaves, whereas the specific activities exhibited a
K. B. Kumar, G. B. Mohanty, S. Patnaik, A. Bhuyan, P. A. Khan   +4 more
openaire   +1 more source

P. aeruginosa CtpA protease adopts a novel activation mechanism to initiate the proteolytic process

The EMBO Journal
During bacterial cell growth, hydrolases cleave peptide cross-links between strands of the peptidoglycan sacculus to allow new strand insertion.
Hao-Chi Hsu, Michelle Wang, Amanda Kovach, Andrew J Darwin, Huilin Li   +4 more
doaj   +1 more source

Enzimas proteolíticas relacionadas con la enfermedad periodontal inflamatoria

Revista Cubana de Estomatología, 1998
La enfermedad periodontal inflamatoria ocasiona la destrucción de los tejidos que protegen y soportan al diente; es por eso de gran importancia el papel que pueden desempeñar las enzimas que sean capaces de degradar la matriz del tejido conectivo, como ...
Bárbara E. García Triana, Agustín Vicedo Tomey,, José C García Piñeiro, Alberto Saldaña Bernabeu   +3 more
doaj  

A peptide filtering relation quantifies MHC class I peptide optimization [PDF]

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Phillips, Andrew, Emmott, Stephen, Mark Howarth, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Dalchau, Neil, Goldstein, Leonard D., Cardelli, Luca, Tim Elliott, Neil Dalchau, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Joern M Werner, Stephen Emmott, Howarth, Mark, Cardelli Luca, Emmott Stephen, Elliott Tim, Werner Joern M., Goldstein Leonard D., Dalchau Neil, Phillips Andrew, Howarth Mark   +25 more
core   +1 more source

Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan

Frontiers in Microbiology, 2019
The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least constituted of peptidoglycan (PG) but also of (lipo)teichoic acids, various polysaccharides, polyglutamate and/or proteins. During bacterial growth and division, there
Aurore Vermassen, Sabine Leroy, Régine Talon, Christian Provot, Magdalena Popowska, Mickaël Desvaux   +5 more
doaj   +1 more source