Results 31 to 40 of about 572,875 (296)

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile

Microbial Cell, 2018
Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj   +1 more source

Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]

, 2003
A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Dekker, P.J.T., Basten, E.J.W., Schaap, P.J.   +2 more
core   +1 more source

Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide [PDF]

Molecular Neurodegeneration, 2009
Abstract Background The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain including monomers, oligomers, and aggregates, and in senile plaques, fibrils.
Yamin, Rina, Zhao, Cheng, O'Connor, Peter B., McKee, Ann C., Abraham, Carmela R.   +4 more
openaire   +4 more sources

Age Dependent Changes of Certain Peptide Hydrolases and Dehydrogenases in Bovine Dental Pulp

, 1969
The concentrations of certain peptide hydrolases and enzymes of the aerobic and anaerobic catabolic cycles in the fibroblasts of bovine dental pulp have been examined as a function of the developmental stage of the tissue.
Christian Schwabe
core   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

eLife
Phage-derived peptidoglycan hydrolases (i.e. lysins) are considered promising alternatives to conventional antibiotics due to their direct peptidoglycan degradation activity and low risk of resistance development.
Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang   +11 more
doaj   +1 more source

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

mBio, 2023
The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks.
Anja P. Keller, Markus Huemer, Chun-Chi Chang, Srikanth Mairpady Shambat, Caroline Bjurnemark, Nicole Oberortner, Michaela V. Santschi, Léa V. Zinsli, Christian Röhrig, Anna M. Sobieraj, Yang Shen, Fritz Eichenseher, Annelies S. Zinkernagel, Martin J. Loessner, Mathias Schmelcher   +14 more
doaj   +1 more source

Rahnella sp., a Dominant Symbiont of the Core Gut Bacteriome of Dendroctonus Species, Has Metabolic Capacity to Degrade Xylan by Bifunctional Xylanase-Ferulic Acid Esterase

Frontiers in Microbiology, 2022
Rahnella sp. ChDrAdgB13 is a dominant member of the gut bacterial core of species of the genus Dendroctonus, which is one of the most destructive pine forest bark beetles. The objectives of this study were identified in Rahnella sp. ChDrAdgB13 genome the
Rosa María Pineda-Mendoza, Gerardo Zúñiga, María Fernanda López, María Eugenia Hidalgo-Lara, Alejandro Santiago-Hernández, Azucena López-López, Flor N. Rivera Orduña, Claudia Cano-Ramírez   +7 more
doaj   +1 more source

Cathepsin E (EC 3.4.23.34) — a review

Folia Histochemica et Cytobiologica, 2012
Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska, Marek Gacko, Michał Chlabicz, Radosław Łapiński   +3 more
doaj   +1 more source

Parameters of blood short-chain peptides and digestive hydrolases in patients with chronic hepatitis B virus infection

Инфекция и иммунитет, 2021
The aim of the study was to examine specifics of changes in the level of stomach- and pancreas-released blood hydrolases in chronic viral hepatitis B and analyze the mechanisms underlying such changes.
M. A. Zhuraeva, V. A. Aleinik, N. D. Ashuralieva, D. S. Halikova, J. B. Ravzatov, B. K. Abdulazizhozhyv   +5 more
doaj   +1 more source