Results 171 to 180 of about 379,196 (358)

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Quantifiable peptide library bridges the gap for proteomics based biomarker discovery and validation on breast cancer. [PDF]

Sci Rep, 2023
Kim SS, Shin H, Ahn KG, Park YM, Kwon MC, Lim JM, Oh EK, Kim Y, Han SM, Noh DY.   +9 more
europepmc   +1 more source

Identification of an allosteric binding site on the transcription factor p53 using a phage-displayed peptide library [PDF]

, 1998
Mark W. Ravera, Juan M. Cárcamo, R E Brissette, Ameena Alam-Moghé, Olga Vasilyevna Dedova, W. T. K. Cheng, Ku-chuan Hsiao, D Klebanov, Han‐Ming Shen, Pi-Pei Tang, Arthur J. Blume, Włodek Mandecki   +11 more
openalex   +1 more source

Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Activation of HTR2B suppresses osteosarcoma progression through the STAT1‐NLRP3 inflammasome pathway and promotes OASL1+ Macrophage production to enhance anti‐tumor immunity. Abstract Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis.
Zhen Huang, Jiazhuang Zhu, Jianping Hu, Xingkai Wang, Xiaolong Ma, Enjie Xu, Kunpeng Zhu, Chunlin Zhang   +7 more
wiley   +1 more source

Rapid Identification of Highly Active and Selective Substrates for Stromelysin and Matrilysin Using Bacteriophage Peptide Display Libraries [PDF]

, 1995
Matthew M. Smith, Lihong Shi, Marc Navre
openalex   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

The identification of CD4 ⁺ T cell epitopes with dedicated synthetic peptide libraries [PDF]

, 1997
Hoebert S. Hiemstra, Gaby Duinkerken, Willemien E. Benckhuijsen, Reinout Amons, René R. P. de Vries, Bart O. Roep, Jan W. Drijfhout   +6 more
openalex   +1 more source

A Solution‐Based Deposition Method Enabling Pigment Blue Edible Electrochemical Transistors

Advanced Science, EarlyView.
A novel solution‐based method is presented to produce Copper Phthalocyanine fibrous films displaying effective ion permeability and enhanced transconductance in electrolyte‐gated transistors architectures. Using these films, the first instance of a fully edible electrolyte‐gated transistor with volumetric capacitance, targeting in‐body applications, is
Alessandro Luzio, Fabrizio M. Ferrarese, Matteo Butti, Alberto D. Scaccabarozzi, Bojan Petrović, Sanja Kojić, Goran Stojanović, Simone Fiorini Granieri, Shubham Tanwar, Adrica Kyndiah, Mario Caironi   +10 more
wiley   +1 more source

Resemblance-Ranking Peptide Library to Screen for Binders to Antibodies on a Peptidomic Scale. [PDF]

Int J Mol Sci, 2022
Jenne F, Biniaminov S, Biniaminov N, Marquardt P, von Bojničić-Kninski C, Popov R, Seckinger A, Hose D, Nesterov-Mueller A.   +8 more
europepmc   +1 more source

Selection of HIV-Specific Immunogenic Epitopes by Screening Random Peptide Libraries with HIV-1-Positive Sera [PDF]

, 1999
Giuseppe Scala, Xueni Chen, Weimin Liu, Jean Noël Telles, Oren J. Cohen, Mauro Vaccarezza, Tatsu Igarashi, Anthony S. Fauci   +7 more
openalex   +1 more source