Results 171 to 180 of about 435,750 (350)

Construction and Application of a Plasmid-Based Signal Peptide Library for Improved Secretion of Recombinant Proteins with Priestia megaterium. [PDF]

Microorganisms, 2022
Mayer J, Knuuti T, Baumgarten L, Menke E, Bischoff L, Bunk B, Biedendieck R.   +6 more
europepmc   +1 more source

Combinatorial Peptide Ligand Libraries as a “Trojan Horse” in Deep Discovery Proteomics

, 2014
Pier Giorgio Righetti, Giovanni Candiano, Attilio Citterio, Egisto Boschetti   +3 more
openalex   +2 more sources

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Identification of a Novel Serological Marker in Seronegative Rheumatoid Arthritis Using the Peptide Library Approach. [PDF]

Front Immunol, 2021
Bason C, Barbieri A, Martinelli N, Olivieri B, Argentino G, Bartoloni E, Beri R, Jadav G, Puccetti A, Tinazzi E, Lunardi C.   +10 more
europepmc   +1 more source

Exponential Combination of a and e/g Intracellular Peptide Libraries Identifies a Selective ATF3 Inhibitor [PDF]

Miao Yu, T. M. Simon Tang, Lila Ghamsari, Graham Yuen, Claudio Scuoppo, Jimmy A. Rotolo, Barry J. Kappel, Jody M. Mason   +7 more
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

The Construction of a Genetically Encoded, Phage-Displayed Cyclic-Peptide Library. [PDF]

Methods Mol Biol, 2021
Chen PC, Liu WR.
europepmc   +1 more source

Phage display libraries of differently sized bicyclic peptides

, 2012
Inmaculada Rentero Rebollo, Alessandro Angelini, Christian Heinis   +2 more
openalex   +2 more sources

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Focused peptide library screening as a route to a superior affinity ligand for antibody purification. [PDF]

Sci Rep, 2021
Bozovičar K, Jenko Bizjan B, Meden A, Kovač J, Bratkovič T.   +4 more
europepmc   +1 more source