Results 131 to 140 of about 200,834 (306)

DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. [PDF]

Cell Rep Phys Sci, 2023
Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM.   +6 more
europepmc   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

Development of peptide nucleic acid-based bead array technology for Bacillus cereus detection. [PDF]

Sci Rep, 2023
Noppakuadrittidej P, Charlermroj R, Makornwattana M, Kaew-Amdee S, Waditee-Sirisattha R, Vilaivan T, Praneenararat T, Karoonuthaisiri N.   +7 more
europepmc   +1 more source

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Triplex-Forming Peptide Nucleic Acid Controls Dynamic Conformations of RNA Bulges. [PDF]

J Am Chem Soc, 2023
Ryan CA, Rahman MM, Kumar V, Rozners E.
europepmc   +1 more source

Oligonucleotide Determination via Peptide Nucleic Acid Macromolecular Imprinting in an Electropolymerized CG-Rich Artificial Oligomer Analogue

, 2018
Katarzyna Bartold, Agnieszka Pietrzyk‐Le, Karolina Golebiewska, Wojciech Lisowski, Silvia Cauteruccio, Emanuela Licandro, Francis D’Souza, Włodzimierz Kutner   +7 more
openalex   +2 more sources

A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA [PDF]

, 2016
Zhengyang Zeng, Shisong Han, Wei Hong, Yange Lang, Fangfang Li, Yongxiang Liu, Zeyong Li, Yingliang Wu, Wenxin Li, Xian‐Zheng Zhang, Zhijian Cao   +10 more
openalex   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria. [PDF]

Bioconjug Chem
Siekierska I, Trylska J.
europepmc   +1 more source

In vivo interference of pea aphid endosymbiont Buchnera groEL gene by synthetic peptide nucleic acids [PDF]

Kathrine Xin Yee Tan, Shuji Shigenobu
openalex   +1 more source