Results 131 to 140 of about 686,761 (347)
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling+4 more
wiley +1 more source
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang+8 more
wiley +1 more source
This study introduces a novel chitosan‐based nanocarrier functionalized with a neurotropic protein for efficient siRNA delivery to neurons. The polyplexes demonstrate enhanced neuronal binding, retrograde transport, and PTEN silencing, promoting axonal outgrowth.
Ana P. Spencer+10 more
wiley +1 more source
Atomic Structures of all the Twenty Essential Amino Acids and a Tripeptide, with Bond Lengths as Sums of Atomic Covalent Radii [PDF]
Recently, the bond lengths of the molecular components of nucleic acids and of caffeine and related molecules were shown to be sums of the appropriate covalent radii of the adjacent atoms. Thus, each atom was shown to have its specific contribution to the bond length. This enabled establishing their atomic structures for the first time.
arxiv
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba+8 more
wiley +1 more source
Self-assembled antibody multimers through peptide nucleic acid conjugation.
With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and evaluate bispecific or higher order multispecific molecules could facilitate the discovery of new therapeutic agents. Here, we show that unnatural amino acids
Stephanie A. Kazane+9 more
semanticscholar +1 more source
Molecular structure and interactions of nucleic acid components in nanopaticles: ab initio calculations [PDF]
Self-associates of nucleic acid components (stacking trimers and tetramers of the base pairs of nucleic acids) and short fragments of nucleic acids are nanoparticles (linear sizes of these particles are more than 10 A. Modern quantum-mechanical methods and softwares allow one to perform ab initio calculations of the systems consisting of 150-200 atoms ...
arxiv
Beta‐glucans have gained significant attention as an immunomodulatory biomaterial with cell‐targeting capabilities. This review comprehensively outlines the design and fabrication methods for producing beta‐glucan particles at both the micro and nanoscale and their applications in immune cell targeting, immunomodulation, and drug delivery ...
Nate Dowdall, Todd Hoare
wiley +1 more source
Super‐Resolution Goes Viral: T4 Virus Particles as Versatile 3D‐Bio‐NanoRulers
Various super‐resolution fluorescence microscopy methods achieve nanoscale resolution, vital for visualizing subcellular structures. Choosing suitable biological standards is challenging, demanding precise geometry and specific labeling capabilities. Utilizing T4 bacteriophage as a 3D‐Bio‐NanoRuler is proposed.
José Ignacio Gallea+10 more
wiley +1 more source
Electron microscopy mapping of oligopurine tracts in duplex DNA by peptide nucleic acid targeting [PDF]
Vadim V. Demidov+7 more
openalex +1 more source