Results 121 to 130 of about 209,856 (252)

Advances in peptide nucleic acid for targeting RNA and genomic DNA. [PDF]

Cell Rep Phys Sci
De A, Kumar V, Saltzman WM, Slack FJ, Vikram A, Gupta A, Bahal R.   +6 more
europepmc   +1 more source

DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. [PDF]

Cell Rep Phys Sci, 2023
Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM.   +6 more
europepmc   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Modulating backbone flexibility in hydroxamate siderophores for improved iron chelation and peptide nucleic acid delivery into bacteria. [PDF]

Biochem J
Tsylents U, Maj P, Wdowiak M, Stadnicki J, Mieczkowski A, Wojciechowska M, Trylska J.   +6 more
europepmc   +1 more source

Development of peptide nucleic acid-based bead array technology for Bacillus cereus detection. [PDF]

Sci Rep, 2023
Noppakuadrittidej P, Charlermroj R, Makornwattana M, Kaew-Amdee S, Waditee-Sirisattha R, Vilaivan T, Praneenararat T, Karoonuthaisiri N.   +7 more
europepmc   +1 more source

Peptide Nucleic Acid (PNA) Hybridization to Nucleic Acid Targets

, 2004
Peptide nucleic acid (PNA) is a DNA/RNA mimic that offers many advantages for hybridization to nucleic acid targets. The simple premise of Watson-Crick base-pairing presents PNAs with a number of diverse applications ranging fromnanotechnology to ...
Nulf, Christopher J.
core  

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

Advanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo   +9 more
wiley   +1 more source

Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria. [PDF]

Bioconjug Chem
Siekierska I, Trylska J.
europepmc   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Designing Programmable Peptide Nucleic Acid-based Nanovaccines for Anticancer Immune Activation. [PDF]

Small
Huang Y, Huang C, Pandita S, Ieong CM, Wang Y, Wang D, Chen J, Jauregui-Matos V, Beelen AMA, Shiau YP, Tang S, Zhao J, Zong Q, Tang M, Cong Z, Li Y, Beal PA, David SS, Wang A, Wang D, Xiao Z, Lam KS.   +21 more
europepmc   +1 more source