Results 111 to 120 of about 205,916 (160)
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Olefinic Peptide Nucleic Acid (OPA)
Nucleosides, Nucleotides and Nucleic Acids, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Gautschi D, Leumann CJ
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Applications of peptide nucleic acids
Current Opinion in Biotechnology, 1999Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
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Peptide nucleic acids: Expanding the scope of nucleic acid recognition
Trends in Biotechnology, 1997Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible ...
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Peptide Nucleic Acids for MicroRNA Targeting
2020The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R. +5 more
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Antisense Properties of Peptide Nucleic Acid
1998The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
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, 1998 A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole +3 more
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Nucleobase Modified Peptide Nucleic Acid
Nucleosides, Nucleotides and Nucleic Acids, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
R H E, Hudson +3 more
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Synthesis of Peptide Nucleic Acid–Peptide Conjugates
2004Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
Kunihiro, Kaihatsu, David R, Corey
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