Results 91 to 100 of about 209,856 (252)

Peptide nucleic acid as antibacterial agents via the antisense principle

, 2001
antibiotics, antisense, bacteria, oligonucleotide, peptide nucleic acid ...
Nielsen, Peter Eigil
core  

-Amino Acid Mimic of Tryptophan for Probing Peptide–Nucleic Acid Complexes

, 2012
International audienceNon-natural amino acids are important tools for site-selective probing of peptide properties and interactions. Here, for the first time a fluorescent l-amino acid, exhibiting excited-state intramolecular proton transfer (ESIPT) and ...
Viktoriia Y. Postupalenko, Volodymyr V. Shvadchak, Andrey S. Klymchenko, Guittet, Eric, Eric Guittet, Klymchenko, Andrey S, Nelly Morellet, Strizhak, Aleksandr V, Yves Mély, Shvadchak, Volodymyr V, Morellet, Nelly, Vasyl G. Pivovarenko, Postupalenko, Viktoriia y, Aleksandr V. Strizhak, Mély, Yves, Pivovarenko, Vasyl   +15 more
core   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Synthesis and characterization of PNA based molecules able to interfere with gene regulation

, 2011
The control of gene expression is a fundamental process to bring the genome to life, and it pervades most of biology, from cell proliferation and differentiation to development. Mis-regulation of gene expression at any level can lead to disease.MicroRNAs,
Avitabile, Concetta
core  

Nucleic Acid and Peptide Aptamers [electronic resource] : Methods and Protocols /

After the deciphering of the human genome and the genomes of many other organisms, the investigation of the function of gene products and their orchestral interplay is now one of the most important challenges in the life sciences.
Mayer, Günter.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service)   +1 more
core   +1 more source

Two-Color Fluorescent l‑Amino Acid Mimic of Tryptophan for Probing Peptide–Nucleic Acid Complexes

, 2016
Non-natural amino acids are important tools for site-selective probing of peptide properties and interactions. Here, for the first time a fluorescent l-amino acid, exhibiting excited-state intramolecular proton transfer (ESIPT) and hydration-sensitive ...
Aleksandr V. Strizhak (1868437), Nelly Morellet (599191), Vasyl G. Pivovarenko (1656610), Yves Mély (1268784), Volodymyr V. Shvadchak (1285122), Andrey S. Klymchenko (1268781), Viktoriia Y. Postupalenko (1868434), Eric Guittet (1478563)   +7 more
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Improved Nucleic Acid Triggered Probe Activation through the Use of a 5-Thiomethyluracil Peptide Nucleic Acid Building Block

, 2016
To improve the efficiency of a nucleic acid triggered probe activation (NATPA) system a 5-thiomethyluracil peptide nucleic acid (PNA) building block has been synthesized.
John Stephen Taylor (2691526), Jianfeng Cai (295870), Xiaoxu Li (12771)   +2 more
core   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Peptide nucleic acid-zirconium coordination nanoparticles. [PDF]

Sci Rep, 2023
Öztürk Ö, Lessl AL, Höhn M, Wuttke S, Nielsen PE, Wagner E, Lächelt U.   +6 more
europepmc   +1 more source