Results 91 to 100 of about 3,183,923 (247)
Comparative Incorporation of PNA into DNA Nanostructures
Molecules, 2015 DNA has shown great promise as a building material for self-assembling nanoscale structures. To further develop the potential of this technology, more methods are needed for functionalizing DNA-based nanostructures to increase their chemical diversity ...
Ronnie O. Pedersen +3 more
doaj +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Aptamers and Their Significant Role in Cancer Therapy and Diagnosis
Biomedicines, 2015 Aptamers are nucleic acid/peptide molecules that can be generated by a sophisticated, well-established technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX).
Joy Sebastian Prakash +1 more
doaj +1 more source
Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2019 Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee +3 more
doaj +1 more source
Peptides, polypeptides and peptide–polymer hybrids as nucleic acid carriers
, 2017 Peptide, polypeptide and polymer–peptide hybrid based nucleic acid therapeutics (NAT).
Marya Ahmed
core +1 more source
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Synthesis and characterization of PNA based molecules able to interfere with gene regulation [PDF]
, 2011 The control of gene expression is a fundamental process to bring the genome to life, and it pervades most of biology, from cell proliferation and differentiation to development. Mis-regulation of gene expression at any level can lead to disease.MicroRNAs,
Avitabile, Concetta
core +1 more source
Nature Communications, 2017 Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short ...
Guizhi Zhu +13 more
doaj +1 more source
Peptide Nucleic Acid Synthons [PDF]
, 2004 A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide ...
Engholm, Michael +3 more
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