Results 81 to 90 of about 3,183,923 (247)

Generation of Nucleic Acid Biopolymers with Complex Functionalities

, 2019
1
OH, SEUNG SOO
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Gene targeting using Peptide Nucleic Acid

, 2004
A brief overview of the properties of the deoxyribonucleic acid mimic peptide nucleic acid (PNA) is given, and the recent progress in cellular delivery of PNA and of using PNA oligomers for antisense and antigene gene targeting is ...
Nielsen, Peter E.
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone

Journal of Nucleic Acids, 2012
The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group.
Trevor A. Feagin, Nirmal I. Shah, Jennifer M. Heemstra   +2 more
doaj   +1 more source

Conjugation and Interaction Studies of Thiol Peptide-based Hydrogels and Peptide Nucleic Acids [PDF]

Peptide Nucleic Acids (PNAs) are synthetic analogues of nucleic acids whose backbones consist of N–(2- aminoethyl)glycine repeats, anchored via amidic bonds.
N. Borbone, G. Oliviero, A. Accardo, C. Diaferia, A. P. Falanga, S. Giordano, E. Gallo   +6 more
core  

Controlled Peptide Capture and Release in 3D‐Printed Multimaterial Microstructures

Advanced Science, EarlyView.
Two‐photon laser printing of 3D microstructures using a peptide‐containing ink is shown. The microstructures allow for controlled capture and release of target peptides through coiled‐coil interaction with the printed peptide inside the material. Based on these properties, orthogonal capture and stimuli‐mediated release possibilities inside printed ...
Niklas Schwegler, Thomas Heim, Philipp Mainik, Eva Blasco, Franziska Thomas   +4 more
wiley   +1 more source

Charge modulation of peptide/nucleic acid complexes: an anionic additive enhances gene silencing and CRISPR/Cas9 editing by promoting intracellular nucleic acid release

Frontiers in Nanotechnology
IntroductionSmall interfering RNA (siRNA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated Protein 9 (Cas9) complexes are effective approaches to temporarily downregulate protein expression via post-transcription ...
Abdulelah Alhazza, Abdulelah Alhazza, Sorour Khayyatnejad Shoushtari, Hasan Uludag, Keykavous Parang, Keykavous Parang, Hamidreza Montazeri Aliabadi   +6 more
doaj   +1 more source

Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate

, 2011
A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized.
Zhang, Da-Wei, Liu, Yan, Yu, Xiao-Qi, Wang, Ming-Qi, Zhao, Yu-Fen, Zhang, Ji, Wang, Jing-Yi, Lin, Hong-Hui, Liu, Jun-Liang, Streckenbach, Frank, Tang, Zhuo   +10 more
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source