Results 81 to 90 of about 393,420 (201)

Aptamers and Their Significant Role in Cancer Therapy and Diagnosis

Biomedicines, 2015
Aptamers are nucleic acid/peptide molecules that can be generated by a sophisticated, well-established technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX).
Joy Sebastian Prakash, Karunanithi Rajamanickam   +1 more
doaj   +1 more source

A Novel Peptide Nucleic Acid against the Cytidine Monophosphate Kinase of S. aureus Inhibits Staphylococcal Infection In Vivo

Molecular Therapy: Nucleic Acids, 2019
Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee, Se Kye Kim, Jun Bong Lee, Jang Won Yoon   +3 more
doaj   +1 more source

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

Nature Communications, 2017
Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short ...
Guizhi Zhu, Lei Mei, Harshad D. Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C. Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen   +13 more
doaj   +1 more source

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Nature Communications, 2019
DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materials ...
Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit   +13 more
doaj   +1 more source

A Brief Review of Aptamer-Based Biosensors in Recent Years

Biosensors
Aptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ...
Wenjing Wang, Yumin He, Suxiang He, Lei Deng, Hui Wang, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin   +8 more
doaj   +1 more source

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

PLoS ONE, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
Gabriel C Uguru, Madhav Mondhe, Shan Goh, Andrew Hesketh, Mervyn J Bibb, Liam Good, James E M Stach   +6 more
doaj   +1 more source

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry

Nature Communications
The RNA-peptide world hypothesis postulates the early co-evolution of RNA and peptides that led to the emergence of non-enzymatic RNA replication and peptide synthesis.
Karina K. Nakashima, Fatma Zohra Mihoubi, Jagandeep S. Saraya, Kieran O. Russell, Fidan Rahmatova, James D. Robinson, Maria Julia Maristany, Jan Huertas, Roger Rubio-Sánchez, Rosana Collepardo-Guevara, Derek K. O’Flaherty, Claudia Bonfio   +11 more
doaj   +1 more source

peptide nucleic acid

Citation: 'peptide nucleic acid' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09714 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. [PDF]

, 2019
Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization.
Chua, Katrin F, Coan, John P, Elias, Joshua E, Gozani, Or, Krajewski, Krzysztof, Li, Tie-Mei, Strahl, Brian D, Zhang, Lichao   +7 more
core   +1 more source

Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.

Тонкие химические технологии, 2007
Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya, Yu. G. Kirillova, D. S. Esipov, V. I. Shvets   +3 more
doaj