Targeting the hard to reach: Challenges and novel strategies in the treatment of intracellular bacterial infections: Targeting intracellular bacteria [PDF]
, 2016 Infectious diseases continue to threaten human and animal health and welfare globally, impacting millions of lives and causing substantial economic loss. The use of antibacterials has been only partially successful in reducing disease impact.
Good, L, Kamaruzzaman, N F, Kendall, S L
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Phage display selected magnetite interacting Adhirons for shape controlled nanoparticle synthesis [PDF]
, 2015 Adhirons are robust, well expressing, peptide display scaffold proteins, developed as an effective alternative to traditional antibody binding proteins for highly specific molecular recognition applications.
Bramble, Jonathan P. +8 more
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Optimization of synthetic route to PNA-T-OH monomers
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications.
Onur Alptürk, Z. Sevcan Yeşilbaş
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Synthesis of PNA Oligoether Conjugates
Molecules, 2014 Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues.
Alice Ghidini +3 more
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Bayesian sequence learning for predicting protein cleavage points [PDF]
, 2005 A challenging problem in data mining is the application of efficient techniques to automatically annotate the vast databases of biological sequence data.
Mayo, Michael
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Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]
, 2009 A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath +3 more
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Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. [PDF]
, 1988 The major hepatitis B virus (HBV) core protein is a viral structural protein involved in nucleic acid binding. Its coding sequence contains an extension of 29 codons (the "precore" region) at the amino terminus of the protein which is present in a ...
Garcia, PD +3 more
core
PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor
Biosensors, 2016 A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Leyla Esfandiari +7 more
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Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone
Journal of Nucleic Acids, 2012 The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group.
Trevor A. Feagin +2 more
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Comparative Incorporation of PNA into DNA Nanostructures
Molecules, 2015 DNA has shown great promise as a building material for self-assembling nanoscale structures. To further develop the potential of this technology, more methods are needed for functionalizing DNA-based nanostructures to increase their chemical diversity ...
Ronnie O. Pedersen +3 more
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