Results 101 to 110 of about 205,916 (160)

Novel diagnostic biomarkers for pancreatic cancer: assessing methylation status with epigenetic-specific peptide nucleic acid and KRAS mutation in cell-free DNA. [PDF]

Front Oncol
Kim H, Chu J, Do IG, Lee YP, Kim HK, Yang Y, Kwon J, Lee KH, Batochir C, Jo E, Kim KR, Han HS.   +11 more
europepmc   +1 more source

Primer pairs, PCR conditions, and peptide nucleic acid clamps affect fungal diversity assessment from plant root tissues. [PDF]

Mycology
Viotti C, Chalot M, Kennedy PG, Maillard F, Santoni S, Blaudez D, Bertheau C.   +6 more
europepmc   +1 more source

Detection of miR-155 Using Peptide Nucleic Acid at Physiological-like Conditions by Surface Plasmon Resonance and Bio-Field Effect Transistor. [PDF]

Biosensors (Basel)
Lavecchia di Tocco F, Botti V, Cannistraro S, Bizzarri AR.   +3 more
europepmc   +1 more source

Retraction for Prudent et al., "Fluorescence In Situ Hybridization (FISH) and Peptide Nucleic Acid Probe-Based FISH for Diagnosis of Q Fever Endocarditis and Vascular Infections". [PDF]

J Clin Microbiol
American Society for Microbiology.
europepmc   +1 more source

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Antisense properties of peptide nucleic acid

Biochimica Et Biophysica Acta Gene Regulatory Mechanisms, 1999
Peptide nucleic acid (PNA) is a nucleic acid mimic in which the deoxyribose phosphate backbone has been replaced by a pseudo-peptide polymer to which the nucleobases are linked. PNA-oligomers can be synthesized in relatively large amounts, are highly stable in biological environments, and bind complementary DNA and RNA targets with remarkably high ...
Peter E Nielsen, Thomas Bentin
exaly   +4 more sources

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

Biopolymers, 2021
AbstractThe early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs.
Haobo Sun, Jinming Kong, Xueji Zhang
openaire   +2 more sources

Fluorinated Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Hollenstein M, Gautschi D, Leumann CJ
openaire   +3 more sources

Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
openaire   +2 more sources

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ethan A, Englund, Ning, Zhang, Daniel H, Appella   +2 more
openaire   +2 more sources

Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
openaire   +3 more sources