Results 141 to 150 of about 200,834 (306)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Designing Programmable Peptide Nucleic Acid-based Nanovaccines for Anticancer Immune Activation. [PDF]

Small
Huang Y, Huang C, Pandita S, Ieong CM, Wang Y, Wang D, Chen J, Jauregui-Matos V, Beelen AMA, Shiau YP, Tang S, Zhao J, Zong Q, Tang M, Cong Z, Li Y, Beal PA, David SS, Wang A, Wang D, Xiao Z, Lam KS.   +21 more
europepmc   +1 more source

An Orthogonal Nucleic Acid/Peptide Amplification Circuit Enables Protease‐Triggered, Cancer Cell‐Selective PD‐L1 Imaging [PDF]

Bo Wu, Xiulin Yi, Jian Zhao, Lele Li
openalex   +1 more source

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Peptide nucleic acid (PNA) clamps enhance root microbiome profiling in wheat and maize. [PDF]

Environ Microbiome
Mukhtar H, Easterly AC, Bachle KB, Ozorio D, Creech CF, Schachtman DP.   +5 more
europepmc   +1 more source

Modeling Peptide Nucleic Acid Binding Enthalpies Using MM-GBSA. [PDF]

J Phys Chem B, 2022
Goodman J, Attwood D, Kiely J, Coladas Mato P, Luxton R.   +4 more
europepmc   +1 more source

Multifunctional Delivery Systems for Peptide Nucleic Acids [PDF]

, 2020
Stefano Volpi, Umberto Cancelli, Martina Neri, Roberto Corradini   +3 more
openalex   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications. [PDF]

Biomacromolecules
Falanga AP, Farina MV, Cianfoni G, Barolo L, Di Meo C, Borsatti GE, Ghirga F, Botta B, Pisano L, Borbone N, D'Errico S, Paone A, Oliviero G, Quaglio D, Baiocco P.   +14 more
europepmc   +1 more source

Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to αvβ3 Integrin-Expressing Cancer Cells [PDF]

, 2020
Anna Egorova, Alexander Selutin, Marianna Maretina, S. А. Selkov, В. С. Баранов, Anton Kiselev   +5 more
openalex   +1 more source