Results 291 to 300 of about 765,071 (332)
Emergent Chemical Reactivity and Complexity of RNA Condensates
Angewandte Chemie, EarlyView.RNA condensates capable of substrate enrichment and catalysis modulate their environment. Could this start a catalytic selection loop or evolution? Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA.
Samuel Hauf +4 more
wiley +1 more source
Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane
Angewandte Chemie, EarlyView.The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi +4 more
wiley +1 more source
2D Assemblies Based on a Tetraphenylethylene D,L‐Cyclic Peptide Scaffold
Angewandte Chemie, EarlyView.A new scaffold based on four nanotube‐forming cyclic peptide units attached to a tetraphenylethene (TPE) core with pH‐dependent self‐assembly that provides light‐emitting 2D nanosheets with controlled thickness is described. Abstract Two dimensional (2D) materials and aggregation‐induced emission (AIE) fluorophores have recently gained attention due to
Alfonso Bayón‐Fernández +7 more
wiley +1 more source
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Nano letters (Print), 2018
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
semanticscholar +1 more source
One of the biggest obstacles for the use of antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with a drug efflux mechanism. Existing
Yuxin Zhang +12 more
semanticscholar +1 more source
Analytical Chemistry, 2019
Exosomal microRNAs are essential in intercellular communications and disease progression, yet it remains challenging to quantify the expression level due to their small size and low abundance in blood.
Li Liu +9 more
semanticscholar +1 more source
Exosomal microRNAs are essential in intercellular communications and disease progression, yet it remains challenging to quantify the expression level due to their small size and low abundance in blood.
Li Liu +9 more
semanticscholar +1 more source
Analytical Chemistry, 2021
Biofouling caused by the accumulation of biomolecules on sensing surfaces is one of the major problems and challenges to realize the practical application of electrochemical biosensors, and an effective way to counter this problem is the construction of ...
Zhen Song +5 more
semanticscholar +1 more source
Biofouling caused by the accumulation of biomolecules on sensing surfaces is one of the major problems and challenges to realize the practical application of electrochemical biosensors, and an effective way to counter this problem is the construction of ...
Zhen Song +5 more
semanticscholar +1 more source
Peptide nucleic acids harness dual information codes in a single molecule.
Chemical Communications, 2020Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar +1 more source