Results 291 to 300 of about 344,433 (343)

Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
openaire   +3 more sources

Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
openaire   +4 more sources

Peptide-Templated Nucleic Acid Ligation [PDF]

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew Levy, Andrew D. Ellington
openaire   +2 more sources

Olefinic Peptide Nucleic Acid (OPA)

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Christian J. Leumann, Daniel Gautschi
openaire   +4 more sources

Peptide Nucleic Acids for MicroRNA Targeting

2020
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R., Gasparello J., Fabbri E., Borgatti M., Tamanini A., Finotti A.   +5 more
openaire   +3 more sources

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ning Zhang, Ethan A. Englund, Daniel H. Appella   +2 more
openaire   +3 more sources

Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Robert H. E. Hudson, Russell D. Viirre, N. McCourt, J. Tse   +3 more
openaire   +4 more sources

Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
openaire   +2 more sources

Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
Mary Rusckowski, F. Chang, Donald Hnatowich, T. Qu   +3 more
openaire   +3 more sources

Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
openaire   +3 more sources