Results 31 to 40 of about 189,505 (303)
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Pharmaceuticals, 2010 The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo +3 more
doaj +1 more source
International Journal of Food Properties, 2022 The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang +7 more
doaj +1 more source
CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site [PDF]
Nucleic Acids Research, 43 (W1): W419-W424, 2015, 2015 Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins.
arxiv +1 more source
Molecules, 2006 We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones +5 more
doaj +1 more source
Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)
Communications Biology, 2022 Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Iria González-Vasconcellos +4 more
doaj +1 more source
Pharmaceutics, 2023 Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk +5 more
doaj +1 more source
Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator [PDF]
Eleanor F Banwell, Bernard M A G Piette, Anne Taormina, Jonathan G
Heddle; Reciprocal Nucleopeptides as the Ancestral Darwinian Self-Replicator,
Molecular Biology and Evolution, msx292 (2017), 2017 Even the simplest organisms are too complex to have spontaneously arisen fully-formed, yet precursors to first life must have emerged ab initio from their environment. A watershed event was the appearance of the first entity capable of evolution: the Initial Darwinian Ancestor.
arxiv +1 more source
Furan-PNA : a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA [PDF]
, 2016 We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy.
Corradini, Roberto +3 more
core +2 more sources
On the stability of peptide nucleic acid duplexes in the presence of organic solvents [PDF]
, 2007 Nucleic acid double helices are stabilized by hydrogen bonding and stacking forces (a combination of hydrophobic, dispersive and electrostatic forces) of the base pairs in the helix.
Allawi +45 more
core +2 more sources
Synthesis and Purification of Peptide Nucleic Acids [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A. +2 more
openaire +4 more sources