Results 31 to 40 of about 134,053 (282)
Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
Molecules, 2017 The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy.
Roberta D’Agata +2 more
doaj +1 more source
Potential applications of peptide nucleic acid in biomedical domain
Engineering Reports, 2020 Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo ...
Kshitij RB Singh +2 more
doaj +1 more source
Acta Informatica Medica, 2011 Peptide nucleic acid (PNA) is a nucleic acid analog in which the sugar phosphate backbone of natural nucleic acid has been replaced by a synthetic peptide backbone usually formed from N-(2-amino-ethyl)-glycine units. It is chemically stable and resistant to hydrolytic enzyme cleavage and thus not expected to be degraded inside a living cell.
Lipismita Samal, Chinmoy Mishra
openaire +2 more sources
Acid-base and lipophilic properties of peptide nucleic acid derivatives
Journal of Pharmaceutical Analysis, 2021 The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described.
Pramod Thakare +6 more
doaj
Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone
Molecules, 2012 A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA ...
Atsushi Kittaka, Toru Sugiyama
doaj +1 more source
Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
Molecules, 2013 Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino +7 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2016 Staphylococcus aureus infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibiotics.
Mostafa FN Abushahba +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids
Molecules, 2018 Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
doaj +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source