Results 21 to 30 of about 3,183,923 (247)

Peptide-nucleic acid nanostructures for transfection

Biomolecular Concepts, 2012
To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
doaj   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

New peptide nucleic acids for biotechnological applications [PDF]

, 2010
In the present study was designed and realized a new similar to the PNA. It is a chiral nucleo-γ-peptide, dabPNA, isomer of the aegPNA unit and characterized by a 2,4-diaminobutyric acid (DABA)-based backbone carrying the carboxymethylated nucleobase on ...
Castiglione, Mariangela
core   +1 more source

A Convenient Asymmetric Synthesis of a β-amino Ester with Additional Functionalization as a Precursor for Peptide Nucleic Acid (PNA) Monomers

Molecules, 2006
We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones, Mercedes García, M. Rosa Sánchez, Sara H. Domínguez, David Díez, Narciso M. Garrido   +5 more
doaj   +1 more source

A Novel Virus Detection Strategy Enabled by TR512-Peptide-Based Bioorthogonal Capture and Enrichment of Preamplified Nucleic Acid

, 2022
High-cost viral nucleic acid detection devices (e.g., qPCR system) are limited resources for developing counties and rural areas, leading to underdiagnosis or even pandemics of viral infectious diseases.
Wang Wan (1901359), Meng Chen, Xuepeng Dong, Liang Feng (1634440), Yu Liu, Jizhe Zhao, Yu Liu (6938), Mengdie Wang, Xiaobo Zhang, Zhenming Gao, Mingzhen Zhu (12003333), Jizhe Zhao (12316273), Fengya Wang (11435840), Meng Chen (48769), Fengya Wang, Mengdie Wang (7302326), Xuepeng Dong (9930022), Yanan Huang, Chunsheng Li (42144), Hui Zhi (106532), Zhenming Gao (11789955), Hui Zhi, Changxin Huangfu (6658100), Haochen Lv (12316270), Xiaobo Zhang (77133), Mingzhen Zhu, Wang Wan, Changxin Huangfu, Chunsheng Li, Yanan Huang (1828879), Haochen Lv, Liang Feng   +31 more
core   +1 more source

Dynamic changes of differential metabolites and key metabolic pathways of Gastrodia elata Blume during fermentation

International Journal of Food Properties, 2022
The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang, Ling Lin, Lilang Li, Qiji Li, Ming Gao, Xiaosheng Yang, Juan Yang, Chunzhi Xie   +7 more
doaj   +1 more source

Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates [PDF]

, 2021
Peptide nucleic acids (PNAs) are charge-neutral oligonucleotides with emerging potential for treatment of genetic, acquired, and viral diseases, including COVID-19. Their challenging synthesis, however, limits their use for rapid therapeutic intervention
Andrei, Loas, Charlotte E., Farquhar, David E., Verhoeven, Kruttika-Suhas, Phadke, Alexander J., Callahan, Carly K., Schissel, Bryan, Bellaire, Alexander J., Mijalis, Chengxi, Li, Nina, Hartrampf, Bradley, Pentelute, Genwei, Zhang   +11 more
core   +2 more sources

Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications

Pharmaceutics, 2023
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk, Ly Porosk, Lucas R. de Mello, Piret Arukuusk, Emerson R. da Silva, Kaido Kurrikoff   +5 more
doaj   +1 more source

DNA Encoded Biotechnologies for Informative Cancer Diagnostics [PDF]

, 2009
This thesis describes the development of DNA-encoded, multi-parametric, sensing platforms for informative cancer diagnostics. In the first part of this thesis, I will present a technology called “DNA-encoded antibody library (DEAL).” In this approach ...
Kwong, Gabriel Abner
core   +1 more source