Results 21 to 30 of about 209,856 (252)
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
An Introduction to Peptide Nucleic Acid
, 1999 Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands.
Michael Egholm, Peter E. Nielsen
core +2 more sources
Construction of tunable peptide nucleic acid junctions [PDF]
, 2018 We report here the construction of 3-way and 4-way peptide nucleic acid (PNA) junctions as basic structural units for PNA nanostructuring.
Tokura, Y. +11 more
core +1 more source
A Peptide–Nucleic Acid Replicator Origin for Life [PDF]
Trends in Ecology & Evolution, 2020 Evolution requires self-replication. But, what was the very first self-replicator directly ancestral to all life? The currently favoured RNA World theory assigns this role to RNA alone but suffers from a number of seemingly intractable problems. Instead, we suggest that the self-replicator consisted of both peptides and nucleic acid strands.
Piette, Bernard M.A.G. +1 more
openaire +5 more sources
Peptide-Enhanced Nucleic Acid Delivery
, 2005 Numerous barriers, both extracellular and intracellular, hinder successful and efficient nonviral nucleic acid delivery. Due to their small size and ability to specifically recognize and interact with molecular targets, peptides can be incorporated as ...
Suzie H. Pun, Jamie M. Bergen
core +1 more source
The challenge of peptide nucleic acid synthesis
Chemical Society Reviews, 2023 The main strategies for the synthesis of Peptide Nucleic Acids (PNAs): key molecules as DNA/RNA mimics that can hybridize complementary chains of nucleic acids with high affinity and specificity.
K. P. Nandhini +3 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li +6 more
wiley +1 more source
, 2007 We have developed 2'-O-methyloligoribonucleotide and peptide nucleic acid (PNA) based artificial ribonucleases (OBAN's), which in presence of zinc or copper ions cleave a potential therapy target in leukemia, an M-BCR/ABL mRNA model.
Strömberg, R,, Murtola, M,
core +1 more source
Nucleic acid templated synthesis of peptide bonds [PDF]
, 2020 The conventional synthesis of peptides, by reactions performed under highly concentrated conditions or on solid phase, have been widely utilised to produce a variety of oligomers.
Nuñez I Pertiñez, Samuel
core