Results 21 to 30 of about 393,420 (201)

Chemistry of Peptide-Oligonucleotide Conjugates: A Review

Molecules, 2021
Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova, Alesya Fokina, Dmitry Stetsenko   +2 more
doaj   +1 more source

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]

, 2016
The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic, Barbara Gatto, Cristina Parolin, Dan Fabris, Giuseppe Zagotto, Giuseppina Sabatino, Guo J., Ilaria Carli, Laura Sinigaglia, Marta Cappellini, Morellet N., Paolo Rovero, You J. C.   +12 more
core   +2 more sources

Controlled assembly of SNAP-PNA-fluorophore systems on DNA templates to produce fluorescence resonance energy transfer [PDF]

, 2014
The SNAP protein is a widely used self-labeling tag that can be used for tracking protein localization and trafficking in living systems. A model system providing controlled alignment of SNAP-tag units can provide a new way to study clustering of fusion ...
Bader A. N., Bannwarth M., Brun M. A., Campos C., Carrion-Vazquez M., Chakrabarti R., Dadon Z., Daguer J. P., Diaz-Mochon J. J., Donovan C., Feldkamp U., Gautier I., Gholami Z., Gorska K., Gronemeyer T., Harris J. L., Haruki H., Hermanson G. T., Hinner M. J., Huang K.-T., Hussain A. F., Hutchins B. M., Johnsson K., Johnsson N., Juillerat A., Jung D., Kamiya M., Kampmeier F., Kazane S. A., Keppler A., Keppler A., Keppler A., Keppler A., Komatsu T., Lakowicz J. R., Lin M. Z., Lo P. K., Lovrinovic M., Lu H., Maurel D., Menchise V., Niemeyer C. M., Niemeyer C. M., Niemeyer C. M., O’Hare H. M., Pianowski Z. L., Pin J. P., Pouchain D., Prencipe G., Quentin Hanley, Roloff A., Rothemund P. W. K., Rothlingshofer M., Rozners E., Runnels L. W., Sadhu K. K., Scheibe C., Scheibe C., Scheibe C., Seeman N. C., Spinelli N., Sun X., Svensen N., Urbina H. D., Weber G., Weber G., Winssinger N., Yeow E. K. L., Zahra Gholami, Zolmajd-Haghighi Z.   +69 more
core   +1 more source

Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]

, 2012
Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads, Doetsch, Martina, Fürtig, Boris, Lybecker, Meghan, Saxena, Krishna, Schroeder, Renée, Stampfl, Sabine   +6 more
core   +1 more source

Peptide-nucleic acid nanostructures for transfection

Biomolecular Concepts, 2012
To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
doaj   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

GibbsCluster: unsupervised clustering and alignment of peptide sequences [PDF]

, 2017
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and regulate these interactions ...
Alvarez, Bruno, Andreatta, Massimo, Nielsen, Morten   +2 more
core   +2 more sources

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

A Convenient Asymmetric Synthesis of a β-amino Ester with Additional Functionalization as a Precursor for Peptide Nucleic Acid (PNA) Monomers

Molecules, 2006
We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones, Mercedes García, M. Rosa Sánchez, Sara H. Domínguez, David Díez, Narciso M. Garrido   +5 more
doaj   +1 more source

Dynamic changes of differential metabolites and key metabolic pathways of Gastrodia elata Blume during fermentation

International Journal of Food Properties, 2022
The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang, Ling Lin, Lilang Li, Qiji Li, Ming Gao, Xiaosheng Yang, Juan Yang, Chunzhi Xie   +7 more
doaj   +1 more source