Results 21 to 30 of about 205,916 (160)

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

A Convenient Asymmetric Synthesis of a β-amino Ester with Additional Functionalization as a Precursor for Peptide Nucleic Acid (PNA) Monomers

Molecules, 2006
We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones, Mercedes García, M. Rosa Sánchez, Sara H. Domínguez, David Díez, Narciso M. Garrido   +5 more
doaj   +1 more source

Dynamic changes of differential metabolites and key metabolic pathways of Gastrodia elata Blume during fermentation

International Journal of Food Properties, 2022
The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang, Ling Lin, Lilang Li, Qiji Li, Ming Gao, Xiaosheng Yang, Juan Yang, Chunzhi Xie   +7 more
doaj   +1 more source

Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)

Communications Biology, 2022
Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Iria González-Vasconcellos, María A. Cobos-Fernández, Michael J. Atkinson, José Fernandez-Piqueras, Javier Santos   +4 more
doaj   +1 more source

Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications

Pharmaceutics, 2023
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk, Ly Porosk, Lucas R. de Mello, Piret Arukuusk, Emerson R. da Silva, Kaido Kurrikoff   +5 more
doaj   +1 more source

Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support

BMC Biotechnology, 2005
Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario, Picard François J, Boissinot Maurice, Bissonnette Luc, Peytavi Régis, Ho Hoang-Anh, Raymond Frédéric R, Bergeron Michel G   +7 more
doaj   +1 more source

Potential applications of peptide nucleic acid in biomedical domain

Engineering Reports, 2020
Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo ...
Kshitij RB Singh, Parikipandla Sridevi, Ravindra Pratap Singh   +2 more
doaj   +1 more source

Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone

Molecules, 2012
A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA ...
Atsushi Kittaka, Toru Sugiyama
doaj   +1 more source

Differences and Similarities in Protein and Nucleic Acid Structures and Their Biological Interactions

Current Issues in Molecular Biology
Protein and nucleic acid play central roles in biology and pharmaceuticals. Both share a similar architecture made of a backbone and side chains. Protein has a peptide backbone and various side chains, whereas nucleic acid has a phosphate backbone and ...
Tsutomu Arakawa, Taiji Oyama, Tomoto Ura, Suguru Nishinami, Kentaro Shiraki, Teruo Akuta   +5 more
doaj   +1 more source

Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine

Molecules, 2013
Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino, Luigi Russo, Brigida D'Abrosca, Valeria Severino, Severina Pacifico, Gaetano Malgieri, Maria Gaglione, Anna Messere   +7 more
doaj   +1 more source