Results 31 to 40 of about 205,916 (160)

Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide

Molecular Therapy: Nucleic Acids, 2016
Staphylococcus aureus infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibiotics.
Mostafa FN Abushahba, Haroon Mohammad, Mohamed N Seleem   +2 more
doaj   +1 more source

Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids

Molecules, 2018
Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
doaj   +1 more source

Synthesis and Purification of Peptide Nucleic Acids [PDF]

Current Protocols in Nucleic Acid Chemistry, 2002
AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A., Nulf, Christopher J., Corey, David R.   +2 more
openaire   +3 more sources

Peptide-based vectors: recent developments

Biomolecular Concepts, 2014
Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of ...
Cerrato Carmine Pasquale, Lehto Tõnis, Langel Ülo   +2 more
doaj   +1 more source

Peptide‐Peptide Nucleic Acid Hybrid Hydrogel Based on Sequence Programmable Morphological Change for DNA Data Storage

Small Structures
Peptide‐based hydrogels provide biocompatible, stimuli‐responsive platforms, while peptide‐DNA hybrids extend programmability through hybridization‐driven crosslinking. However, nucleobase incorporation can influence peptide self‐assembly pathways.
Huiling Lei, Jinsheng Li, Zixiao Zhang, Zi’an Lin, Guangxu Zhang, Jianjian Huang, Shuhan Dai, Guojiao Wu, Hongmei Liu, Yuzhou Wu   +9 more
doaj   +1 more source

Supporting data for the characterization of PNA–DNA four-way junctions

Data in Brief, 2015
Holliday or DNA four-way junctions (4WJs) are cruciform/bent structures composed of four DNA duplexes. 4WJs are key intermediates in homologous genetic recombination and double-strand break repair.
Douglas Iverson, Crystal Serrano, Ann Marie Brahan, Arik Shams, Filbert Totsingan, Anthony J. Bell Jr.   +5 more
doaj   +1 more source

Deep Eutectic Solvents as Media for the Prebiotic DNA-Templated Synthesis of Peptides

Frontiers in Chemistry, 2020
Translation of genetic information into peptide products is one of the fundamental processes of biology. How this occurred prebiotically, in the absence of enzyme catalysts, is an intriguing question.
Samuel Núñez-Pertíñez, Thomas R. Wilks   +1 more
doaj   +1 more source

Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice.

PLoS ONE, 2010
BackgroundA peptide able to transduce cardiac tissue specifically, delivering cargoes to the heart, would be of significant therapeutic potential for delivery of small molecules, proteins and nucleic acids.
Maliha Zahid, Brett E Phillips, Sean M Albers, Nick Giannoukakis, Simon C Watkins, Paul D Robbins   +5 more
doaj   +1 more source

Optimization of synthetic route to PNA-T-OH monomers

Journal of the Turkish Chemical Society, Section A: Chemistry, 2018
Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications.
Onur Alptürk, Z. Sevcan Yeşilbaş
doaj   +1 more source

Human cathelicidin peptide LL-37 compacts nucleic acids and alters neutrophil extracellular trap structure

Scientific Reports
The human cathelicidin host defense peptide LL-37 is expressed by many cell types, including neutrophils, macrophages, and epithelial cells, and forms complexes with nucleic acids that can have either beneficial or detrimental health effects.
Claudia Zielke, Behzad Rad, Josefine E. Nielsen, Jiaxin Li, Sopida Pimcharoen, Manasi Sawant, Seraphine Kamayirese, Jennifer S. Lin, Hawa R. Thiam, Annelise E. Barron   +9 more
doaj   +1 more source