Results 11 to 20 of about 3,183,923 (247)
Nucleic acid templated synthesis of peptide bonds [PDF]
, 2020 The conventional synthesis of peptides, by reactions performed under highly concentrated conditions or on solid phase, have been widely utilised to produce a variety of oligomers.
Nuñez I Pertiñez, Samuel
core +6 more sources
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber +3 more
core +1 more source
Fluorinated peptide nucleic acid [PDF]
, 2003 The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting ...
Marcel Hollenstein +5 more
core +1 more source
Peptide Nucleic Acid – An Opportunity for Bio-Nanotechnology
CHIMIA, 2014 DNA is a major player in the field of bio-nanotechnology and many interesting applications have been realized using this oligonucleotide. In contrast, the use of peptide nucleic acid (PNA), which is a non-natural, neutral analogue of DNA with ...
Philipp Anstaett, Gilles Gasser
doaj +1 more source
Olefinic peptide nucleic acid (OPA) [PDF]
, 2003 The olefinic peptide nucleic acid analogues (OPA) monomers containing the bases thymine and adenine were synthesised in 11 steps. Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting ...
Gautschi, Daniel, Leumann, Christian
core +1 more source
Peptide Nucleic Acids: Applications in Biomedical Sciences
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
doaj +1 more source
A Review of Peptide Nucleic Acid [PDF]
, 2015 Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone.
Shafiquzzaman Siddiquee +2 more
core +2 more sources
Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
doaj +1 more source
Algorithms for Nucleic Acid Sequence Design [PDF]
, 2010 Motivated by a growing field of research focused on programming function into biomolecules, we seek to decrease the cost of high-quality rational nucleic acid sequence design while increasing its versatility and availability.
Zadeh, Joseph N.
core +1 more source
Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer
Cancer Medicine, 2021 Background Bronchoscopy is a minimally invasive procedure for establishing the diagnosis of lung cancer. It sometimes fails to obtain tissue samples but readily collects cytological samples.
Kazutaka Fujita +9 more
doaj +1 more source