Results 11 to 20 of about 209,856 (252)
Antisense properties of peptide nucleic acid
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999 Peptide nucleic acid (PNA) is a nucleic acid mimic in which the deoxyribose phosphate backbone has been replaced by a pseudo-peptide polymer to which the nucleobases are linked.
Larsen, H J +5 more
core +6 more sources
Peptide Nucleic Acids Complexes of Two Peptide Nucleic Acid Strands and One [PDF]
, 1999 Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity
Engholm, Michael +5 more
core +2 more sources
New peptide nucleic acid analogues: synthesis and applications
Expert Opinion on Biological Therapy, 2007 Peptide nucleic acids are oligonucleotide mimics characterised by high chemical and enzymatic stability, high specificity and affinity toward complementary DNA/RNA.
SAVIANO M +2 more
core +1 more source
A self-replicating peptide nucleic acid [PDF]
Org. Biomol. Chem., 2014 This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Plöger, Tobias A. +1 more
openaire +3 more sources
Peptide nucleic acids in materials science [PDF]
Artificial DNA: PNA & XNA, 2012 This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi +3 more
openaire +3 more sources
Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette, Jacob +3 more
openaire +2 more sources
Peptides for nucleic acid delivery
Advanced Drug Delivery Reviews, 2016 Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Lehto, T +3 more
openaire +3 more sources
Synthesis and Purification of Peptide Nucleic Acids [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A. +2 more
openaire +3 more sources
Silencing disease genes in the laboratory and the clinic
, 2011 Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Jonathan K Watts +3 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source