Results 41 to 50 of about 205,916 (160)
Acta Informatica Medica, 2011 Peptide nucleic acid (PNA) is a nucleic acid analog in which the sugar phosphate backbone of natural nucleic acid has been replaced by a synthetic peptide backbone usually formed from N-(2-amino-ethyl)-glycine units. It is chemically stable and resistant to hydrolytic enzyme cleavage and thus not expected to be degraded inside a living cell.
Chinmoy Mishra, Lipismita Samal
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Synthesis of PNA Oligoether Conjugates
Molecules, 2014 Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues.
Alice Ghidini +3 more
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PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor
Biosensors, 2016 A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli) 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL) depending on cellular rRNA levels.
Leyla Esfandiari +7 more
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Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone
Journal of Nucleic Acids, 2012 The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group.
Trevor A. Feagin +2 more
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Comparative Incorporation of PNA into DNA Nanostructures
Molecules, 2015 DNA has shown great promise as a building material for self-assembling nanoscale structures. To further develop the potential of this technology, more methods are needed for functionalizing DNA-based nanostructures to increase their chemical diversity ...
Ronnie O. Pedersen +3 more
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Aptamers and Their Significant Role in Cancer Therapy and Diagnosis
Biomedicines, 2015 Aptamers are nucleic acid/peptide molecules that can be generated by a sophisticated, well-established technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX).
Joy Sebastian Prakash +1 more
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Molecular Therapy: Nucleic Acids, 2019 Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee +3 more
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Nature Communications, 2017 Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short ...
Guizhi Zhu +13 more
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Nature Communications, 2019 DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materials ...
Vasantha Basavalingappa +13 more
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A Brief Review of Aptamer-Based Biosensors in Recent Years
BiosensorsAptamers have recently become novel probes for biosensors because of their good biocompatibility, strong specificity, and high sensitivity. Biosensors based on peptides or nucleic acid aptamers are used in implantable and wearable devices owing to their ...
Wenjing Wang +8 more
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