Results 41 to 50 of about 765,071 (332)
Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Pharmaceuticals, 2010 The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo +3 more
doaj +1 more source
International Journal of Food Properties, 2022 The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang +7 more
doaj +1 more source
Methods and compositions for stimulating T-lymphocytes [PDF]
, 2003 Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A. +2 more
core +1 more source
Molecules, 2006 We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones +5 more
doaj +1 more source
Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
core +3 more sources
Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. [PDF]
PLoS ONE, 2010 BACKGROUND: A peptide able to transduce cardiac tissue specifically, delivering cargoes to the heart, would be of significant therapeutic potential for delivery of small molecules, proteins and nucleic acids.
Maliha Zahid +5 more
doaj +1 more source
Thermal Stability of Peptide Nucleic Acid Complexes.
Journal of Physical Chemistry B, 2019 Peptide nucleic acid (PNA) is a neutral nucleic acid analogue that base pairs with itself and natural nucleic acids. PNA-nucleic acid complexes are more thermally stable than the corresponding complexes of natural nucleic acids.
M. Jasiński +3 more
semanticscholar +1 more source
Pharmaceutics, 2023 Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk +5 more
doaj +1 more source
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]
, 2016 Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen +2 more
core +1 more source
Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)
Communications Biology, 2022 Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Iria González-Vasconcellos +4 more
doaj +1 more source