Results 71 to 80 of about 200,834 (306)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Aptamers and Their Significant Role in Cancer Therapy and Diagnosis

Biomedicines, 2015
Aptamers are nucleic acid/peptide molecules that can be generated by a sophisticated, well-established technique known as Systematic Evolution of Ligands by EXponential enrichment (SELEX).
Joy Sebastian Prakash, Karunanithi Rajamanickam   +1 more
doaj   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

A Novel Peptide Nucleic Acid against the Cytidine Monophosphate Kinase of S. aureus Inhibits Staphylococcal Infection In Vivo

Molecular Therapy: Nucleic Acids, 2019
Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee, Se Kye Kim, Jun Bong Lee, Jang Won Yoon   +3 more
doaj   +1 more source

Peptide nucleic acid–dependent artifact can lead to false-positive triplex gene editing signals

, 2021
Pui Yan Ho, Zhen Zhang, Mark Hayes, Andrew Curd, Carla Dib, Maire Rayburn, Sze Nok Tam, Tumul Srivastava, Brandon Hriniak, Xiaojun Li, Scott F. Leonard, Lan Wang, Somayeh S. Tarighat, Derek Sim, Mark J. Fiandaca, James Coull, Allen Ebens, Marshall Fordyce, Agnieszka Czechowicz   +18 more
openalex   +2 more sources

Front Cover: Self‐Assembly of Hybrid Peptide−DNA Nanostructures using Homotrimeric Coiled‐Coil/Nucleic Acid Building Blocks (ChemBioChem 17/2023) [PDF]

, 2023
Alex Buchberger, Md Al‐Amin, C.R. Simmons, Nicholas Stephanopoulos   +3 more
openalex   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Nature Communications, 2019
DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materials ...
Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit   +13 more
doaj   +1 more source

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).

PLoS ONE, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
Gabriel C Uguru, Madhav Mondhe, Shan Goh, Andrew Hesketh, Mervyn J Bibb, Liam Good, James E M Stach   +6 more
doaj   +1 more source

Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format

, 2021
Harsha Amarasekara, K.M. Oshaben, Kendra B. Jeans, Paniz Rezvan Sangsari, Nicole Y. Morgan, Brian O’Farrell, Daniel H. Appella   +6 more
openalex   +2 more sources