Results 71 to 80 of about 189,505 (303)
Evaluation of the Protein Recognition Properties of Peptide Nucleic Acids [PDF]
, 2015 The objective is to evaluate the ability of aminoacyl-tRNA synthetases (aaRS) to recognize the non-standard nucleic acid, PNA (peptide nucleic acid). PNA has immense potential in biomedical applications due to its increased thermostability and nuclease ...
Serrano, Crystal Cox
core +1 more source
Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
core +1 more source
Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids [PDF]
, 2020 The conditions that led to the formation of the first organisms and the ways that life originates from a lifeless chemical soup are poorly understood.
Altay, Meniz +9 more
core +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Molecular Dynamics Analysis of Biomolecular Systems Including Nucleic Acids [PDF]
arXiv, 2021 Along with recent progress in structural biology and genome biology, structural dynamics of molecular systems including nucleic acids has attracted attention in the context of gene regulation. Structure-function relationship is an important topic, where physicochemical properties of nucleotides are important as well as those of amino acids in proteins.
arxiv
Reprogramming the assembly of unmodified DNA with a small molecule [PDF]
, 2016 The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA ‘alphabet’ by synthetic incorporation of new bases can introduce new functionalities and enable the ...
A Chworos +58 more
core +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Peptide-based vectors: recent developments
Biomolecular Concepts, 2014 Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of ...
Cerrato Carmine Pasquale +2 more
doaj +1 more source
Advanced Functional Materials, EarlyView.The newly developed, combined 3D‐extrusion bioprinting process of a collagen ink and a recombinant spider silk precipitation bath with a subsequent potassium phosphate post‐treatment fabricates spider silk particle‐reinforced, fibrillar collagen scaffolds with promising properties for soft tissue engineering.
Kim Sarah Koeck +2 more
wiley +1 more source
Deep Eutectic Solvents as Media for the Prebiotic DNA-Templated Synthesis of Peptides
Frontiers in Chemistry, 2020 Translation of genetic information into peptide products is one of the fundamental processes of biology. How this occurred prebiotically, in the absence of enzyme catalysts, is an intriguing question.
Samuel Núñez-Pertíñez +1 more
doaj +1 more source