Results 11 to 20 of about 2,973,844 (208)
PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs
Analytical Chemistry, 2023 Monitoring diseases caused by pathogens or by mutations in DNA sequences requires accurate, rapid, and sensitive tools to detect specific nucleic acid sequences. Here, we describe a new peptide nucleic acid (PNA)-based nucleic acid detection toolkit, termed PNA-powered diagnostics (PNA-Pdx). PNA-Pdx employs PNA probes that bind specifically to a target
Wenjun Jiang +4 more
core +5 more sources
Synthesis of peptide nucleic acid (PNA) and entrapment of PNA into liposomes [PDF]
, 2004 DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ...
He, Peng
openaire +2 more sources
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS)
Ultrasonics Sonochemistry, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene +9 more
doaj +4 more sources
Journal of Peptide Science, 2013 The 2‐(o‐nitrophenyl)‐propyl (NPP) group is used as caging group to mask the nucleobases adenine and cytosine in N‐(2‐aminoethyl)glycine peptide nucleic acids (aeg‐PNA). The adeninyl and cytosinyl nucleo amino acid building blocks Fmoc‐aNPP‐aeg‐OH and Fmoc‐cNPP‐aeg‐OH were synthesized and incorporated into PNA sequences by Fmoc solid phase synthesis ...
Guha, Samit +3 more
openaire +4 more sources
Nanotechnology for delivery of peptide nucleic acids (PNAs) [PDF]
Journal of Controlled Release, 2016 Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide chemistries.
Anisha Gupta +4 more
openaire +2 more sources
Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates [PDF]
, 2021 Peptide nucleic acids (PNAs) are charge-neutral oligonucleotides with emerging potential for treatment of genetic, acquired, and viral diseases, including COVID-19. Their challenging synthesis, however, limits their use for rapid therapeutic intervention
Andrei, Loas +11 more
core +2 more sources
Peptide Nucleic Acid (PNA) Hybridization to Nucleic Acid Targets [PDF]
, 2004 Peptide nucleic acid (PNA) is a DNA/RNA mimic that offers many advantages for hybridization to nucleic acid targets. The simple premise of Watson-Crick base-pairing presents PNAs with a number of diverse applications ranging fromnanotechnology to ...
Nulf, Christopher J.
core +3 more sources
Comparative Incorporation of PNA into DNA Nanostructures
Molecules, 2015 DNA has shown great promise as a building material for self-assembling nanoscale structures. To further develop the potential of this technology, more methods are needed for functionalizing DNA-based nanostructures to increase their chemical diversity ...
Ronnie O. Pedersen +3 more
doaj +1 more source
Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine
Molecules, 2013 Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino +7 more
doaj +1 more source
Frontiers in Microbiology, 2022 The physical and chemical properties of the outer membrane of Gram-negative bacteria including Escherichia coli have a significant impact on the antibacterial activity and uptake of antibiotics, including antimicrobial peptides and antisense peptide ...
Lise Goltermann +6 more
doaj +1 more source