Results 31 to 40 of about 2,973,844 (208)
Peptide nucleic acid-zirconium coordination nanoparticles
Scientific Reports, 2023 Ideal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the therapeutic cargo
Özgür Öztürk +6 more
doaj +1 more source
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber +3 more
core +1 more source
Microorganisms, 2022 Legionella are opportunistic intracellular pathogens that are found throughout the environment. The Legionella contamination of water systems represents a serious social problem that can lead to severe diseases, which can manifest as both Pontiac fever ...
Montserrat Nácher-Vázquez +8 more
doaj +1 more source
Synthesis and characterization of PNA based molecules able to interfere with gene regulation [PDF]
, 2011 The control of gene expression is a fundamental process to bring the genome to life, and it pervades most of biology, from cell proliferation and differentiation to development. Mis-regulation of gene expression at any level can lead to disease.MicroRNAs,
Avitabile, Concetta
core +1 more source
Acid-base and lipophilic properties of peptide nucleic acid derivatives
Journal of Pharmaceutical Analysis, 2021 The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described.
Pramod Thakare +6 more
doaj +1 more source
PNA/DNA chimeras for biotechnological applications [PDF]
, 2006 [ITALIANO] Argomento della presente tesi è l’applicazione di chimere al campo terapeutico e diagnostico. E’ stata innanzitutto realizzata una sintesi conveniente di monomeri Mmt-PNA, una nuova strategia per l’ottenimento di un linker oltre all ...
Roviello, Giovanni
core +1 more source
Cooperative strand displacement by peptide nucleic acid (PNA)
Chemistry & Biology, 1998 Synthetic homopyrimidine peptide nucleic acids (PNAs) can bind complementary targets in double-stranded DNA, generating strand-displacement complexes, and so offering an opportunity to modulate specific gene expression. Several issues remain to be addressed before these attributes can be exploited in vivo, however.The kinetics of the interaction ...
Kurakin, A. +2 more
openaire +2 more sources
DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation. [PDF]
PLoS ONE, 2013 Non-small cell lung cancer (NSCLC) patients treated with small molecule EGFR inhibitors, such as gefitinib, frequently develop drug resistance due to the presence of secondary mutations like the T790M mutation on EGFR exon 20.
Minakshi Guha +2 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2019 Here, we report a novel bactericidal peptide nucleic acid (PNA) that can induce the antisense effect on the cytidine monophosphate kinase (Cmk) of Staphylococcus aureus, a putative essential component for bacterial species.
Hyung Tae Lee +3 more
doaj +1 more source
Diagnostics, 2023 Although circulating tumour DNA (ctDNA)-based next-generation sequencing (NGS) is a less invasive method for assessing ESR1 mutations that are essential mechanisms of endocrine therapy resistance in patients with oestrogen receptor-positive breast cancer,
Yuki Kojima +16 more
doaj +1 more source