Results 41 to 50 of about 2,973,844 (208)

Recent developments in the delivery of peptide nucleic acids (PNAs). [PDF]

RSC Chem Biol
PNAs have strong therapeutic potential but poor cellular uptake. This graphic highlights approaches like backbone modification, transporter conjugation, and nanoparticle encapsulation that have improved delivery and enhanced antisense activity.
Sarkar S, Murthy N.
europepmc   +3 more sources

Nucleic Acid Sensors onto Peptide Nucleic Acid (PNA) Surface

International Journal of Scientific Research in Science and Technology, 2021
A biosensor is defined as “a device that uses specific biochemical signal mediated by isolated enzymes, immunosystems, tissues, organelles or whole cells to detect chemical compounds usually by electrical, thermal or optical signals” [1]. A sensor comprises of at least two basic steps, first, target detection and second, signal transduction. The target
openaire   +1 more source

An Introduction to Peptide Nucleic Acid

, 1999
Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands.
Michael Egholm, Peter E. Nielsen
core   +3 more sources

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Frontiers in Microbiology, 2019
Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding ...
Lise Goltermann, Niloofar Yavari, Meiqin Zhang, Anubrata Ghosal, Peter E. Nielsen   +4 more
doaj   +1 more source

Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer [PDF]

, 2019
Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to
Hector, Argueta-Gonzalez, Colin, Swenson, Jennifer, Heemstra, Arventh, Velusamy   +3 more
core   +2 more sources

Label-Free Potentiometry for Detecting DNA Hybridization Using Peptide Nucleic Acid and DNA Probes

Sensors, 2013
Peptide nucleic acid (PNA) has outstanding affinity over DNA for complementary nucleic acid sequences by forming a PNA-DNA heterodimer upon hybridization via Watson-Crick base-pairing.
Yuji Miyahara, Hiroshi Aoki, Masaki Torimura, Ankit Balram Singi, Akira Matsumoto, Yasuhiro Maeda, Tatsuro Goda   +6 more
doaj   +1 more source

A Convenient Asymmetric Synthesis of a β-amino Ester with Additional Functionalization as a Precursor for Peptide Nucleic Acid (PNA) Monomers

Molecules, 2006
We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones, Mercedes García, M. Rosa Sánchez, Sara H. Domínguez, David Díez, Narciso M. Garrido   +5 more
doaj   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source

Fluorogenic PNA probes

Beilstein Journal of Organic Chemistry, 2018
Fluorogenic oligonucleotide probes that can produce a change in fluorescence signal upon binding to specific biomolecular targets, including nucleic acids as well as non-nucleic acid targets, such as proteins and small molecules, have applications in ...
Tirayut Vilaivan
doaj   +1 more source

Preparation and identification of 177Lu-labeled DOTA-anti-CITED1-PNA and its effect on proliferation of human papillary thyroid cancer K1 cells

Di-san junyi daxue xuebao, 2019
Objective To prepare and characterize 177Lu-DOTA-anti-CIITED1-PNA, a 177Lu-labled antisense probe for the antisense peptide nucleic acid (asPNA) of Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 (CITED1) mRNA and assess ...
LI Jia, WANG Zhengjie, ZHANG Lei, WANG Ying, HUANG Huan   +4 more
doaj   +1 more source