Results 61 to 70 of about 2,973,844 (208)

The Disobeying 'Soldier': Use of an Achiral Group to Modulate Chiral Induction in PNA Duplexes

CHIMIA, 2018
Peptide nucleic acid (PNA) is a synthetic analogue of DNA in which the natural nucleobases A, G, C, and T are linked to an achiral, charge neutral, pseudopeptide backbone.
Artur Sargun, Yanhaomin Fang, Catalina Achim   +2 more
doaj   +1 more source

Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma. [PDF]

PLoS ONE, 2013
Direct sequencing remains the most widely used method for the detection of epidermal growth factor receptor (EGFR) mutations in lung cancer; however, its relatively low sensitivity limits its clinical use.
Hye Sook Kim, Jae Sook Sung, Song-Ju Yang, Nak-Jung Kwon, LiHua Jin, Seung Tae Kim, Kyong Hwa Park, Sang Won Shin, Han Kyeom Kim, Jin-Hyoung Kang, Jeong-Oh Kim, Jae Yong Park, Jin Eun Choi, HyoungKyu Yoon, Chan Kwon Park, Kap-Seok Yang, Jeong-Sun Seo, Yeul Hong Kim   +17 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Control of electron transfer in DNA by peptide nucleic acids (PNA) [PDF]

Nucleic Acids Symposium Series, 2000
The one-electron oxidation of PNA-DNA hybrid containing G-triplet sequence was examined. In DNA duplex G-triplet was selectively cleaved by oxidation, whereas in PNA-DNA hybrid cleavage efficiency was extremely lowered. These result suggested that cleavage efficiency of PNA-DNA hybrid was different from that of B-form DNA duplex.
K, Tanabe, K, Yoshida, C, Dohno, A, Okamoto, I, Saito   +4 more
openaire   +2 more sources

PNA Microprobe for Label-Free Detection of Nucleic Acid Repeat Mutations [PDF]

, 2021
We present a PNA-based microprobe sensing platform to detect nucleic acid repeat mutations by electrochemical impedance spectroscopy. The microprobe platform discriminated Huntington’s disease-associated CAG repeats in cell-derived total RNA.
Grace, Durocher, Kizito-Tshitoko , Tshilenge, Mohtashim, Shamsi, Narges , Asefifeyzabadi, Lisa, Ellerby   +4 more
core   +2 more sources

Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support

BMC Biotechnology, 2005
Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario, Picard François J, Boissinot Maurice, Bissonnette Luc, Peytavi Régis, Ho Hoang-Anh, Raymond Frédéric R, Bergeron Michel G   +7 more
doaj   +1 more source

Therapeutic and diagnostic applications of antisense peptide nucleic acids

Molecular Therapy: Nucleic Acids
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland, Madeline Kravitz, Anisha Gupta   +2 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, Volume 13, Issue 52, 18 September 2026.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone

Journal of Nucleic Acids, 2012
The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group.
Trevor A. Feagin, Nirmal I. Shah, Jennifer M. Heemstra   +2 more
doaj   +1 more source

Shelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells

Aging Cell, Volume 25, Issue 9, September 2026.
Elongation of telomeres by increasing TPP1, through genetic and pharmacological approaches, promotes hair follicle bulge stem cell mobilization and migration, leading to accelerated telogen‐to‐anagen transition and hair regeneration. This work identifies TPP1 as a master regulator and therapeutic target for alopecia. ABSTRACT Telomere shortening drives
Lihui Wang, Bihan Zhao, Jiahui Yang, Ying Liang, Yitian Yao, Xiao Xiao, Long Yang, Jinghao Xia, Haoze Li, Ling Gao, Jun Zhang, Tianci Su, Hao Xu, Jiacheng Zhang, Hongyan Wang, Jun Liu, Xiaojing Hong, Jun‐Ping Liu   +17 more
wiley   +1 more source