Results 71 to 80 of about 2,973,844 (208)
, 2010 Antigene RNAs (agRNAs) are small RNA duplexes that target non-coding transcripts rather than mRNA and specifically suppress or activate gene expression in a sequence-dependent manner.
Charisse, Klaus +6 more
core +1 more source
Construction of tunable peptide nucleic acid junctions [PDF]
, 2018 We report here the construction of 3-way and 4-way peptide nucleic acid (PNA) junctions as basic structural units for PNA nanostructuring.
Tokura, Y. +11 more
core +1 more source
Peptide Nucleic Acid – An Opportunity for Bio-Nanotechnology
CHIMIA, 2014 DNA is a major player in the field of bio-nanotechnology and many interesting applications have been realized using this oligonucleotide. In contrast, the use of peptide nucleic acid (PNA), which is a non-natural, neutral analogue of DNA with ...
Philipp Anstaett, Gilles Gasser
doaj +1 more source
Timing‐Dependent Clearance of p16‐Positive Cells Mitigates Radiation‐Induced Accelerated Aging
Aging Cell, Volume 25, Issue 9, September 2026.Genotoxic stress induces a progressive accelerated aging‐like phenotype driven by the delayed accumulation of p16Ink4a‐positive senescent cells. Selective clearance of these cells improves healthspan, tissue function, and survival only when initiated after senescent cells have accumulated, highlighting a critical therapeutic window for senescence ...
Karla Valdivieso +15 more
wiley +1 more source
ViewPeptide nucleic acid (PNA) is a synthetic analog of DNA, uniquely characterized by a charge‐neutral peptide backbone that imparts resistance to enzymatic degradation and enhances hybridization specificity.
Younghwan Kim, Swomitra Kumar Mohanty
doaj +1 more source
New Phytologist, Volume 251, Issue 6, Page 3507-3521, September 2026.Synthetic community complexity reduction designs. Summary Plant growth is influenced by the composition of its associated microbiome. The inherent complexity and functional redundancy of natural plant microbiomes present a formidable barrier to understanding the myriad biological interactions therein.
Dean Pettinga +8 more
wiley +1 more source
Prospects for antisense peptide nucleic acid (PNA) therapies for HIV [PDF]
Expert Opinion on Biological Therapy, 2009 Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation or transcription processes.
Virendra N, Pandey +2 more
openaire +2 more sources
Electrochemical Science Advances, Volume 6, Issue 4, August 2026.ABSTRACT Rapid and sensitive detection of disease‐related biomarkers is critical for early diagnosis and appropriate treatment. However, conventional analytical methods are often time‐consuming and require complex procedures and skilled personnel.
Minju Ahn +4 more
wiley +1 more source
Peptide nucleic acid (PNA) conformation and polymorphism in PNA-DNA and PNA-RNA hybrids. [PDF]
Proceedings of the National Academy of Sciences, 1993 Two hydrogen-bonding motifs have been proposed to account for the extraordinary stability of polyamide "peptide" nucleic acid (PNA) hybrids with nucleic acids. These interresidue- and intraresidue-hydrogen-bond motifs were investigated by molecular mechanics calculations. Energy-minimized structures of Watson-Crick base-paired decameric duplexes of PNA
O, Almarsson, T C, Bruice
openaire +2 more sources
Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone
Molecules, 2012 A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA ...
Atsushi Kittaka, Toru Sugiyama
doaj +1 more source