Results 91 to 100 of about 2,973,844 (208)

Intracellular Localization of PNA in Human Cells upon its Introduction by Electroporation

Natural Product Communications, 2012
Peptide nucleic acid (PNA) is one of the most useful DNA analogs in a wide variety of gene analysis in human cells. In order to exhibit its maximal functions, PNA must be localized to a desired place (e.g., nucleus, cytoplasm and other organelles). Here,
Eri Noguchi, Narumi Shigi, Makoto Komiyama   +2 more
doaj   +1 more source

Synthesis, Properties and Functions of Peptide Nucleic Acids (PNA) and Their Derivatives.

Journal of Synthetic Organic Chemistry, Japan, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Iwase, Reiko, Murakami, Akira
openaire   +2 more sources

Localization of Trinucleotide Repeat Sequences in Myotonic Dystrophy Cells Using a Single Fluorochrome-Labeled PNA Probe

BioTechniques, 1998
A labeled peptide nucleic acid (PNA) antisense probe was used to study the spatial distribution of triplet repeats (CTG) in human myotonic dystrophy (DM) cells by high-resolution fluorescence in situ hybridization (FISH).
Krishan L. Taneja
doaj   +1 more source

PNA-nucleic acid complexes. Structure, stability and dynamics

, 1997
BiokemiGrowing interest in gene targeting drugs has inspired the development of a multitude of nucleic acid analogues, many of which feature substitutions in the phosphodiester moiety of the backbone (reviewed by Mesmaeker et al. 1995 and Nielsen, 1995).
Nielsen, Peter Eigil, Eriksson, Magdalena   +1 more
core   +1 more source

Structural and biological properties of peptide nucleic acid (PNA

, 1998
: The chemical, physical and biological properties of PNA (peptide nucleic acid) is briefly reviewed. In particular, recent X-ray crystallography and NMR structural data on PNA complexes are discussed.
Nielsen, Peter Eigil, Peter E. Nielsen
core  

Antibacterial Peptide Nucleic Acid–Antimicrobial Peptide (PNA–AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

, 2016
Antisense peptide nucleic acid (PNA) oligomers constitute a novel class of potential antibiotics that inhibit bacterial growth via specific knockdown of essential gene expression.
Gitte Bonke, Anna Mette Hansen, Peter E. Nielsen (8833), Hansen, Anna Mette, Bonke, Gitte, Camilla Josephine Larsen, Gitte Bonke (2496622), Franzyk, Henrik, Peter E. Nielsen, Henrik Franzyk (454386), Nielsen, Peter E., Niloofar Yavari, Yavari, Niloofar, Larsen, Camilla Josephine, Henrik Franzyk, Niloofar Yavari (2555629), Camilla Josephine Larsen (2555626), Anna Mette Hansen (2533210)   +17 more
core   +1 more source

Microcalorimetry and fluorescence show stable peptide nucleic acid (PNA) duplexes in high organic content solvent mixtures [PDF]

, 2019
The selectivity of nucleic acid hybridisation can be exploited to template chemical reactions, enabling materials discovery by chemical evolution. However, to date the range of reactions that can be used has been limited to those that are compatible with
Wilks, Thomas; id_orcid, O'Reilly, Rachel; id_orcid, Nuñez-Pertiñez, Samuel   +2 more
core   +1 more source

A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA

Molecular Therapy: Nucleic Acids, 2016
Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all of which are severe threats to human health.
Zhengyang Zeng, Shisong Han, Wei Hong, Yange Lang, Fangfang Li, Yongxiang Liu, Zeyong Li, Yingliang Wu, Wenxin Li, Xianzheng Zhang, Zhijian Cao   +10 more
doaj   +1 more source

Supporting data for the characterization of PNA–DNA four-way junctions

Data in Brief, 2015
Holliday or DNA four-way junctions (4WJs) are cruciform/bent structures composed of four DNA duplexes. 4WJs are key intermediates in homologous genetic recombination and double-strand break repair.
Douglas Iverson, Crystal Serrano, Ann Marie Brahan, Arik Shams, Filbert Totsingan, Anthony J. Bell Jr.   +5 more
doaj   +1 more source

PNA-Dependent Gene Chemistry: Stable Coupling of Peptides and Oligonucleotides to Plasmid DNA

BioTechniques, 2000
Two approaches are described for stably conjugating peptides, proteins and oligonucleotides onto plasmid DNA. Both methods use a peptide nucleic acid (PNA) clamp, which binds irreversibly and specifically to a binding site cloned into the plasmid.
O. Zelphati, X. Liang, C. Nguyen, S. Barlow, S. Sheng, Z. Shao, P.L. Felgner   +6 more
doaj   +1 more source