Results 81 to 90 of about 2,973,844 (208)
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Bloodstream infections (BSIs) pose a significant global health challenge, particularly in developing countries. Neonates are highly vulnerable due to underdeveloped immune systems and immature physical barriers, a risk amplified by poor hygiene and limited healthcare access in low‐ and middle‐income countries (LMICs), leading to an ...
Alex Odoom +4 more
wiley +1 more source
iMeta, Volume 5, Issue 4, August 2026.From ecological principles to precision engineering of plant microbiomes for sustainable agriculture. The plant holobiont integrates diverse microbial niches (including rhizosphere, endosphere, phyllosphere, seed, and aerial‐root mucilagesphere), host genetics (namely M genes), and host metabolites. Furthermore, molecular dialogues, including rhizobial
Mi Wei +26 more
wiley +1 more source
Peptide nucleic acids (PNAs): currently potential bactericidal agents
Biomedicine & Pharmacotherapy, 2017 In recent years, the emergence of ESBL-producing and multi-drug resistant bacteria have been increased and designing novel components is necessary for confrontation these bacteria. Peptide nucleic acids (PNAs) are one of the synthetic components that bind to single strand DNA and RNA.
Hanar, Narenji +5 more
openaire +2 more sources
Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.
Тонкие химические технологии, 2007 Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya +3 more
doaj
Synthesis and Improved Cross-Linking Properties of C5-Modified Furan Bearing PNAs
Molecules, 2017 Over the past decades, peptide nucleic acid/DNA (PNA:DNA) duplex stability has been improved via backbone modification, often achieved via introducing an amino acid side chain at the α- or γ-position in the PNA sequence.
Joke Elskens +4 more
doaj +1 more source
Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford +1 more
wiley +1 more source
Gene targeting using Peptide Nucleic Acid
, 2004 A brief overview of the properties of the deoxyribonucleic acid mimic peptide nucleic acid (PNA) is given, and the recent progress in cellular delivery of PNA and of using PNA oligomers for antisense and antigene gene targeting is ...
Nielsen, Peter E.
core +1 more source
Potential applications of peptide nucleic acid in biomedical domain
Engineering Reports, 2020 Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo ...
Kshitij RB Singh +2 more
doaj +1 more source
PNA-protein conjugates for nano-scale modeling of protein aggregates [PDF]
, 2013 Programmable assembly of proteins on molecular frameworks requires the development of facile and orthogonal chemical approaches and molecular scaffolds.
Gholami, Z
core
Olefinic peptide nucleic acid (OPA) [PDF]
, 2003 The olefinic peptide nucleic acid analogues (OPA) monomers containing the bases thymine and adenine were synthesised in 11 steps. Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting ...
Gautschi, Daniel, Leumann, Christian
core +1 more source